What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
AIR → carboxyaminoimidazole ribonucleotide (CAIR)
Converts 5-Aminoimidazole ribonucleotide (AIR) into Carboxyaminoimidazole ribonucleotide (CAIR)
› Notes
AIR carboxylase catalyzes AIR + CO2 (derived from bicarbonate) → CAIR. In mammalian cells, the class II AIR carboxylase activity of PAICS performs direct carboxylation and does not require ATP; this differs from the two-enzyme, ATP-dependent bacterial route. The carboxyl carbon becomes C6 of the purine ring.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Integrating bulk and single-cell transcriptomic data to construct a risk model for histidine metabolism-related epithelial cell features in lung adenocarcinoma, predicting prognosis and immune landscape.
Mao C, Zhou L. · 2026-04-28
cited 1× open access unreviewed -
2
HSP60 and HSP10 depletion provoke distinct biological responses.
Ben-David H, Gabbay S, Sued-Hendrickson S, Cohen L, Levin L, Tickotsky Moskovitz N, Abramovich I, Dror S, Bro… · 2026-10-01
open access unreviewed -
3
10,11-Dehydrocurvularin suppresses non-small cell lung cancer by targeting PAICS and inducing apoptosis.
Wang Y, Chen S, Huang P, Rehmutulla M, Xiao Y, Duan Y, Fu Y, Xia X, Wei J, Hu Z, Tong Q, Zhang Y. · 2026-08-13
unreviewed -
4
Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis.
Hall B, Ebrahim YM, Sharpe JL, Makhija S, Ellis BCS, Wong KE, Walker H, Yagüe-Capilla M, Timmons HO, Bradley … · 2026-09-16
open access unreviewed -
5
Exploratory Association of 5' and 3' UTRs Variants in <i>TYMS</i> and <i>CCND1</i> with Severe Hematologic Toxicity in Pediatric Acute Lymphoblastic Leukemia.
Rojo-Serrato D, Flores-Murrieta FJ, Rosas-Vargas H, Jiménez-Hernández E, Núñez-Enríquez JC, González-Torres C… · 2026-09-12
open access unreviewed -
6
Evaluating AI-assisted detection of fetal intracranial malformations in prenatal ultrasound practice: a multicentre, self-crossover, randomised controlled trial in China.
Lei T, Shang N, Xie B, Luo Y, Zheng H, Li H, Zhang C, Wang N, Zhou Q, Xie H. · 2026-09-10
unreviewed -
7
Artificial intelligence in assisted localization of fetal ultrasound standard planes: a narrative review.
Wang K, Lei L, Liu Z, Huang Y, Wei Q, He W, Jin L, Du M, Chen Z. · 2026-08-05
open access unreviewed -
8
N6-methyladenosine-mediated upregulation of PAICS promotes lung-adenocarcinoma metastasis via the integrin-FAK signaling.
Zhang M, Zhu J, Zhang H, Zhang J, Zhao J, Chen Q, Zeng Y, Li J, Huang JA, Liu Z. · 2026-07-23
unreviewed -
9
Indirect Comparison of the Efficacy of Zanubrutinib vs Ibrutinib and Acalabrutinib in Treatment-Naive Chronic Lymphocytic Leukemia: 6-Year Follow-Up.
Shadman M, Munir T, Xu S, Yang K, Mohseninejad L, Guthrie G, Hirata J, Lefebure M, Williams R, Tam CS. · 2026-06-11
open access unreviewed -
10
Guanidinoacetic acid improves flesh quality associated with collagen synthesis and nucleotide metabolism in gibel carp CAS V (<i>Carassius gibelio</i>, CAS V).
Wang Y, Zhang Y, Wu L, Li C, Chen Q, Han D, Liu H, Zhang Z, Xie S, Jin J. · 2026-04-03
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.