What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
AIR → carboxyaminoimidazole ribonucleotide (CAIR)
Converts 5-Aminoimidazole ribonucleotide (AIR) into Carboxyaminoimidazole ribonucleotide (CAIR)
› Notes
AIR carboxylase catalyzes AIR + CO2 (derived from bicarbonate) → CAIR. In mammalian cells, the class II AIR carboxylase activity of PAICS performs direct carboxylation and does not require ATP; this differs from the two-enzyme, ATP-dependent bacterial route. The carboxyl carbon becomes C6 of the purine ring.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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