What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Maleylacetoacetate → fumarylacetoacetate
Converts Maleylacetoacetate into Fumarylacetoacetate
› Notes
Maleylacetoacetate isomerase uses glutathione as a cofactor. The isomerization prepares the molecule for hydrolytic cleavage.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Targeting GSTZ1 Sensitizes KRASG12C-Mutant Lung Cancer Cells by Overcoming Glutathione and Glycolysis Pathway Rewiring.
Liao Y, Li X, Liu M, Fernandes VC, Duckett D, Haura EB, Monastyrskyi A, Rix U. · 2026-06-01
open access unreviewed -
2
Specific knockout of kidney homogentisate 1,2-dioxygenase reveals that local metabolism of tyrosine and homogentisic acid is negligible in alkaptonuria.
Rutland DA, Norman BP, Hughes JH, Wilson PJM, Sutherland H, Brown RLW, Gallagher JA, Ranganath LR, Bou-Ghario… · 2026-05-01
open access unreviewed -
3
Bacillus velezensis EU07 suppresses Fusarium graminearum via transcriptomic reprogramming.
Baysal Ö, Jimenez-Quiros C, Cevher-Keskin B, Tör M. · 2026-05-08
open access unreviewed -
4
Genomic and functional insights into aromatic compound degradation by <i>Delftia</i> strain PS-11 isolated from freshwater pufferfish.
Archana Kujur RR, Deb S, Debnath T, Papade S, Phale PS, Das SK. · 2026-04-01
open access unreviewed -
5
Quantitative Succinylacetone Measurement by Gas Chromatography-Tandem Mass Spectrometry (GC-MS/MS) Facilitates Diagnosis, Monitoring, and Characterization of Tyrosinemia Type 1 and Other Hypersuccinylacetonemias.
Cyr D, Maranda B, Waters PJ. · 2026-02-27
open access unreviewed -
6
Integrated Transcriptomic and Proteomic Analyses Uncover the Mechanisms of Keratin Degradation in <i>Lysobacter brunescens</i> YQ20.
Wei MY, Gao X, Zhao XT, Liu Y, Zhao CY, Li H, An WM, Zhang DX, Zhang F, Ma Q, Yu JF. · 2026-02-12
open access unreviewed -
7
Homogentisic Acid Disrupts the Blood-Brain Barrier and Promotes Aβ Aggregation in Alzheimer's Disease.
Liu X, Xu QQ, Zhang YB, Yuan SY, Huang WL, Pi MS, Xiong Q, Gui YR, Deng SC, Wan L, Xiao YF, Wang XC, Shu XJ, … · 2026-02-05
unreviewed -
8
Molecular mechanisms underlying the inhibition of <i>Sparassis latifolia</i> mycelial growth by cycloleucine: a comprehensive transcriptomic and m6A methylome analysis.
Yang C, Wu D, Xiao D, Jiang X, Lin H, Wang X, Lin Y, Ma L. · 2026-02-28
open access unreviewed -
9
ΔFW-NPS6-Dependent Transcriptome Profiling Reveals Putative Pathogenicity Genes in <i>Fusarium oxysporum</i>.
Ye X, Zhang L, Zhang J, Lu H, Li J, Zou H. · 2026-01-14
open access unreviewed -
10
Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β.
Shinno K, Miura Y, Iijima KM, Suzuki E, Ando K. · 2026-01-26
cited 1× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.