Malate-alpha-ketoglutarate antiporter (SLC25A11)
What it does, reaction by reaction
Malate-Aspartate Shuttle Energy Metabolism & Cellular Respiration · Cytosol + inner mitochondrial membrane
Malate(cytosol) + alpha-ketoglutarate(matrix) <-> malate(matrix) + alpha-ketoglutarate(cytosol)
Converts Malate(cytosol) alpha-ketoglutarate(matrix) < into Malate(matrix) Alpha-ketoglutarate
› Notes
Transport step, not enzymatic.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Neutrophil extracellular traps in cardiovascular disease: Mechanisms and therapeutic implications (Review).
Wang Z, Chang M, Shang W, Jia Y, Shan X, Chen X, Yang Y, Zhang J. · 2026-09-25
open access unreviewed -
2
Glutamine Metabolism in Health and Diseases.
Ding Y, Tong F, Zeng J, Cui CP. · 2026-09-29
open access unreviewed -
3
Neutrophil Extracellular Traps in Atherosclerosis and Cardiovascular Disease.
Zhang J, Wei F, Qu M, Shao Y, Xu T, Stojkov D, Simon HU, Huang B, Miao C, Zhang H. · 2026-09-15
open access unreviewed -
4
Iron metabolism and ferroptosis in cardiovascular diseases: progress in the mechanism and pharmacological intervention.
Jiang Y, Zhang J, Zeng L, Li Y, Wang D, Li Y, Sun L, Fan F. · 2026-07-29
open access unreviewed -
5
Malate-aspartate shuttle inactivation drives pulmonary hypertension through glucose carbon flux rewiring and α-ketoglutarate-dependent epigenetic remodeling.
Wang Y, Liang Q, Gao Y, Geng J, Cheng X, Xin M, Guo D, Sun D, Hu L, Li Y, Jin F. · 2026-09-15
open access unreviewed -
6
Preserved mitochondrial respiration in presence of oxidative stress and reduced mitochondrial mass after 10-day bed rest in older adults.
Motanova E, Zuccarelli L, Lysenko E, Amoretti S, Pirazzini M, Rossetto O, Brocca L, Bottinelli R, Pellegrino … · 2026-09-11
open access unreviewed -
7
Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta.
Jung EM, Ieronimakis N, Mousa B, Sheikh ED, Ligon SE, Monson JW, Damicis JR, Kinsman HJ, Bettridge LE, Arnold… · 2026-09-01
open access unreviewed -
8
Noncoding RNA encoded peptides in tumors from discovery to mechanism and clinical translation.
Zhou D, Li H, Yang J, He M, Yang L, Jian L. · 2026-08-24
open access unreviewed -
9
Ferroptosis: Newly Emerged Regulator for Human Disease.
Xiao D, Ye L, Jiang T, Liu M, Zhou Y. · 2026-08-19
cited 1× open access unreviewed -
10
Rare Molecular Variants of Gastrointestinal Stromal Tumors (GISTs): Clinical Implications and Overview of Current Evidence.
Klimczak A, Kisielewska K, Szumera-Ciećkiewicz A, Rutkowski P. · 2026-08-12
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.