Malate-alpha-ketoglutarate antiporter (SLC25A11)
What it does, reaction by reaction
Malate-Aspartate Shuttle Energy Metabolism & Cellular Respiration · Cytosol + inner mitochondrial membrane
Malate(cytosol) + alpha-ketoglutarate(matrix) <-> malate(matrix) + alpha-ketoglutarate(cytosol)
Converts Malate(cytosol) alpha-ketoglutarate(matrix) < into Malate(matrix) Alpha-ketoglutarate
› Notes
Transport step, not enzymatic.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin.
Sternisha AC, Li H, Gajendra K, Xiao Y, Zhao X, Traylor JI, Guo L, Jun JH, Fleishman M, Shipman T, Puliyappad… · 2026-07-16
unreviewed -
2
The GAPP Aggressivity Score Correlates with Total Enriched Somatic Variant Burden in Sporadic Pheochromocytoma—A Pilot Study
Halperin R, Goldinger G, Fridman E, Yaloz N, Tirosh A, Shlomai G. · 2026-06-01
open access unreviewed -
3
Mitochondrial Dynamics and SLC25 Transporters in Neurodegeneration: From Mechanisms to Therapeutic Opportunities
Morciano G, Gorgoglione R, Porcelli V, Ahmed A, Scarcia P, Vozza A, Lasorsa F, Fiermonte G, Palmieri L. · 2026-06-01
open access unreviewed -
4
Long Non-Coding RNAs in Pathogenesis of Renal Cell Carcinoma: Epigenetic Regulation, Signaling Pathways, and Therapeutic Strategies.
Savelieva O, Gilyazova I, Chumakova A, Khusnutdinova E, Pavlov V. · 2026-06-03
open access unreviewed -
5
Novel Mechanism of and Therapeutic Approach for Anthracycline-Induced Cardiotoxicity.
Wang Q, Zhang W, Chen J, Stenson KT, Parsai S, Parthasarathy PB, Liu CF, Garrett T, Lin J, Hou A, Shimpi RA, … · 2026-06-01
open access unreviewed -
6
Lysosomes contribute to the synthesis of tricarboxylic acid-related metabolites in the hippocampus.
Kong L, Tan H, Zhu X, Wen Y, Li Y. · 2026-02-19
open access unreviewed -
7
Research Progress on the Role of Traditional Chinese Medicine in Regulating Ferroptosis in Cardiovascular Diseases.
Li P, Qi ZM, Li SC, Liang JL, Xu TY, Yu P. · 2026-05-23
open access unreviewed -
8
Ectopic Cushing Syndrome due to an Adrenocorticotropic Hormone-Producing Pheochromocytoma.
Stamatiades GA, Bikas A, Shah HJ, Wong KS, Vaidya A, Nehs MA, Basaria SS. · 2026-01-02
open access unreviewed -
9
KLF4 overexpression in CAR T cells enhances antitumor potency by preventing exhaustion.
Wang H, Meng X, Feng Y, Su A, Qin W, Shen J, Lu K, Gu L, Ma Y, Wang Y, Mao Y, Ji D, Zong L, Zheng M, Du Y, Co… · 2026-05-20
open access unreviewed -
10
Genomic and Mitonuclear Patterns of Divergence Among Recently Diverged White-Crowned Sparrow Subspecies.
Osagie PB, Enciso-Romero J, Burg TM. · 2026-05-14
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.