Malate dehydrogenase
Cofactors used
What it does, reaction by reaction
Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix
L-Malate + NAD+ ⇌ oxaloacetate + NADH + H+
Converts Malate NAD+ into Oxaloacetate NADH H+
› Notes
Required cofactor: NAD+. Although the standard free-energy change is unfavorable, the reaction proceeds in vivo because citrate synthase rapidly consumes oxaloacetate; it is reversible and regenerates the acceptor required for the next turn.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Unlocking raw-corncob consolidated bioprocessing for malic acid production by DyP-enabled lignin deconstruction in <i>Myceliophthora thermophila</i>.
Zhang Y, Zhang Y, Han L, Liu J, Liu D, Sun T, Wang D, Li M, Li J, Tian C. · 2026-08-08
open access unreviewed -
2
Metabolic engineering of <i>Escherichia coli</i> for efficient production of d-phenylglycine.
Xiong Y, Shang Z, Lu L, Wang T, Cai G, Shen X, Sun X, Wang J, Yuan Q. · 2026-08-07
open access unreviewed -
3
Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects.
Zhang L, Fan Y, Shi W, Zhou X. · 2026-07-16
open access unreviewed -
4
Advancing our understanding of photosynthesis: discoveries and insights from aquatic plants.
Kazmi A, Li G, Yang J, Zhao X, Islam MF, Li X, Kimura S, Hou H. · 2026-06-29
open access unreviewed -
5
MdWRKY125 bridges cold condition and fruit flavor by activating the sucrose synthase gene <i>MdSUS3</i> in apple.
Zhuang YY, Du LD, Wei MM, Zhang WJ, Wang HC, Zhao TT, Hu DG. · 2026-08-06
open access unreviewed -
6
Natural products alleviate exercise-induced fatigue by modulating gut microbiota: a systematic review.
Yan D, Jiao T. · 2026-09-07
open access unreviewed -
7
Natural products targeting hepatitis B virus X protein and HBx-associated pathways in HBV-related hepatocellular carcinoma: mechanisms and therapeutic potential.
Nguyen TNA, Thongsri P, Pewkliang Y, Chomnawang MT, Thirapanmethee K, Sa-Ngiamsuntorn K. · 2026-09-04
open access unreviewed -
8
Robust structural, kinetic and biophysical characterization of wild-type human ACOD1, selected mutants and their interaction with citraconate.
Runge B, Oktay H, Fucci IJ, Merten EM, Tarasov SG, Fan L, Monteiro DCF. · 2026-08-08
open access unreviewed -
9
SnRK1 in stress adaptation and growth regulation: Insights from <i>Arabidopsis</i> to crops.
Zhong X, Zhang L, Han C, Bai M. · 2026-07-20
open access unreviewed -
10
Mechanistic pathways linking gut microbial metabolites, microbial structural products, and host-microbe co-metabolites to mitochondrial function.
Frye RE, Rossignol DA. · 2026-08-06
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.