Malate dehydrogenase
Cofactors used
What it does, reaction by reaction
Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix
L-Malate + NAD+ ⇌ oxaloacetate + NADH + H+
Converts Malate NAD+ into Oxaloacetate NADH H+
› Notes
Required cofactor: NAD+. Although the standard free-energy change is unfavorable, the reaction proceeds in vivo because citrate synthase rapidly consumes oxaloacetate; it is reversible and regenerates the acceptor required for the next turn.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Role of primary protectors of plant cells in salinity tolerance: molecular mechanisms and adaptive strategies.
Das S, Janeeshma E, Mousavi H, Aronsson H, Sarraf M. · 2026-06-12
open access unreviewed -
2
A commensal protozoan exacerbates acetaminophen-induced liver injury by producing free sphingosine.
Yan X, Shen Y, Sun Q, Zhu X, Chen Q, Liao L, Zhou Y, Cheng W, Shi Z, Liu Z, Wei Y, Liu X, Wang Y, Kou Y. · 2026-06-02
open access unreviewed -
3
The role of protein palmitoylation in disease pathogenesis and therapeutic innovation.
Lin X, Xing J, Jia K, Liu S, Liu Y, Gu Y, Guo K, Yi J. · 2026-05-29
open access unreviewed -
4
Gut microbiota reshapes host energy metabolism to modulate depressive behaviors.
Lei P, Qi Z, Ma Q, Zhao B, Wen B, Jiang W, Xi W, Liu Y, Xun Y, Zhang S, Wang Y, Guo Y, Wang W, Ma X, Jia M, F… · 2026-04-23
open access unreviewed -
5
Repurposing loratadine to reverse colistin resistance in <i>Klebsiella pneumoniae</i> through targeting lipid A modification.
Wu X, Ge Z, Zhan H, Zheng M, Feng Y, Zhai Y, Yuan L, Liu J, Pan Y, Hu G, Ma X, He D. · 2026-02-12
cited 1× open access unreviewed -
6
Exogenous indole promotes florfenicol tolerance in <i>Edwardsiella tarda</i>.
Zheng Y, Fu L, Cao Z, Zhang T, Fei J, Jiang M, Zhou Y, Shi Z, Su Y. · 2026-01-24
cited 1× open access unreviewed -
7
Formate as electron carrier in the gut acetogen <i>Blautia luti</i>: a model for electron transfer in the gut microbiome.
Trischler R, Müller V. · 2026-01-02
cited 2× open access unreviewed -
8
Mitochondrial dysfunction via oxidative stress and calcium imbalance mediates antifungal activity of calcium propionate against Trichothecium roseum.
Chai H, Liu Q, Xu X, Li X, Nan M, Zong Y, Xue H, Bi Y. · 2026-07-09
unreviewed -
9
Co-transplantation of pancreatic islets with adipose-derived mesenchymal stem cells in vascularized kidney ECM scaffolds to restore type 1 diabetes mellitus.
Choi M, Shanto PC, Fahad MAA, Bae SH, Lee BT. · 2026-06-04
open access unreviewed -
10
PM<sub>2.5</sub> exposure impairs mitochondrial function and myocardial contractility in cardiac organoids via the Sirt3/Mdh2 pathway.
Tian L, Li J, Lv J, Liu Z, Liang C, Yang S, Sun Z, Duan J. · 2026-06-29
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.