What it does, reaction by reaction
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Palmitate + CoA + ATP → palmitoyl-CoA + AMP + PPi
Converts Palmitate CoA-SH ATP into Palmitoyl-CoA AMP PPi
› Notes
An endoplasmic-reticulum/outer-mitochondrial-membrane long-chain acyl-CoA synthetase activates palmitate for elongation, desaturation, or glycerolipid synthesis. ATP is cleaved to AMP, costing two ATP equivalents.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Beta-Oxidation of Fatty Acids
Listed there as: Long-chain acyl-CoA synthetase
Fatty-acid availability; CoA and ATP
Product acyl-CoA/limited CoA at high flux
Hormones primarily regulate substrate release rather than this enzyme directly
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
ACSL3 inhibits ferroptosis in gastric cancer through the activation of unfolded protein response following endoplasmic reticulum stress.
Wang H, Jiao J, Yang W, Sun D, Wei M, Sun G, Yan Z, Liang Y, Cheng Z, Yan Y, Wang M, Li Y, Cui X, Yu W. · 2026-07-07
unreviewed -
2
Amyloid-β aggregates induce vasculopathy via ferroptosis in brain endothelial cells.
Son S, Kim S, Jeon MT, Choi M, Kim KS, Lee S, Nah SY, Kim DG. · 2026-03-01
open access unreviewed -
3
Profiling major volatile components in apricot fruit sheds light on the molecular mechanisms underlying low-temperature-mediated volatile release.
Wang H, Sun P, Yang Y, Yu W, Kang Y, Li M, Zhou S, Sun X, Jin M, Jin W, Sun H, Wang Y. · 2026-05-09
open access unreviewed -
4
Coordinated Cell-Wall and Starch Maturation Is Associated with Winter-Harvest Quality in <i>Sparganium stoloniferum</i> Tubers.
Qian X, Pan M, Zhang J, Liu Q, Yang F, Liu C, Sang M, Wu Q. · 2026-05-19
open access unreviewed -
5
Tissue-specific fibroblast lipid cues impose the rate of epithelial cancer invasion.
Budden T, Palombo N, Gurung S, Gutteridge M, Russell C, Marques J, von Kriegsheim A, An L, Harwood C, Motta L… · 2026-04-27
open access unreviewed -
6
Fatty acid metabolic reprogramming in the tumor microenvironment: Unraveling mechanisms and therapeutic prospects.
Zhang W, Wang P, Yuan G, Liu F, Jin G, Zhang J. · 2025-07-14
open access unreviewed -
7
Decoding the spatiotemporal characteristics of ferroptosis: reshaping tumour therapeutic strategies.
Song L, Shu Y, Zhou T, Wang Y, Zhang H, Liao Y, Zhu C, Zhang W, Zou Z. · 2026-04-08
cited 3× open access unreviewed -
8
Metaproteome Analysis of Short‐Term Thermal Stress in Three Sympatric Coral Species Reveals Divergent Host Responses
Nandi S, Stephens T, Chille E, Goyen S, Bay L, Bhattacharya D. · 2026-03-01
open access unreviewed -
9
Phenotypic and Genomic Characterization of Polyethylene-Degrading <i>Bacillus cereus</i> PE-1 Enriched from Landfill Microbial Consortium.
Wang W, Yao S, Liu Z, Liu X. · 2026-03-12
open access unreviewed -
10
BR-C promotes lipid synthesis through the nuclear receptor HR96 during metamorphosis in insects.
Zhang X, Li P, He X, Yuan D, Li H, Sun Q, Cheng D, Qian W. · 2026-01-25
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.