What it does, reaction by reaction
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Palmitate + CoA + ATP → palmitoyl-CoA + AMP + PPi
Converts Palmitate CoA-SH ATP into Palmitoyl-CoA AMP PPi
› Notes
An endoplasmic-reticulum/outer-mitochondrial-membrane long-chain acyl-CoA synthetase activates palmitate for elongation, desaturation, or glycerolipid synthesis. ATP is cleaved to AMP, costing two ATP equivalents.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Beta-Oxidation of Fatty Acids
Listed there as: Long-chain acyl-CoA synthetase
Fatty-acid availability; CoA and ATP
Product acyl-CoA/limited CoA at high flux
Hormones primarily regulate substrate release rather than this enzyme directly
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Integrative Transcriptomic and Metabolomic Analysis Reveals the Molecular Regulatory Mechanisms of Leaf Rust Resistance in <i>Zanthoxylum armatum</i>.
Hu H, Shu C, Sun X, Wang L, Zhang H, Zhou P, Huang X. · 2026-09-16
open access unreviewed -
2
Physiological and Transcriptomic Responses to Cold Stress in Taiwan Loach (<i>Paramisgurnus dabryanus</i> ssp. Taiwan).
Zhou W, Chen J, Hu Y, Li D, Yu T, Shen H. · 2026-08-17
open access unreviewed -
3
Synergistic Application of Cytidine Monophosphate and Sodium Chloride for Enhanced Co-Production of Astaxanthin and Fatty Acids in <i>Haematococcus lacustris</i> Motile Cells Under High-Light Stress.
Su X, Xing H, Liu K, Zhao Y, Dong L, Zhou Z, Zhou N, Sun X, Zhang L, Xu N, Hu C. · 2026-08-19
open access unreviewed -
4
Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk.
Li Y, Mao J, Deng Y, Ge X, Nie L, Wang Q, Wang R, Zhang J, Lyu T, Zhao L, Liu L, Li B. · 2026-08-01
cited 1× open access unreviewed -
5
Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging.
Mehrotra P, Bhamidipati SH, Lei P, Toftegaard J, Choudhury D, Elsayed M, Zhang Y, Wang J, Chitkara S, Atilla-… · 2026-08-01
open access unreviewed -
6
ACSL3 inhibits ferroptosis in gastric cancer through the activation of unfolded protein response following endoplasmic reticulum stress.
Wang H, Jiao J, Yang W, Sun D, Wei M, Sun G, Yan Z, Liang Y, Cheng Z, Yan Y, Wang M, Li Y, Cui X, Yu W. · 2026-07-07
open access unreviewed -
7
Amyloid-β aggregates induce vasculopathy via ferroptosis in brain endothelial cells.
Son S, Kim S, Jeon MT, Choi M, Kim KS, Lee S, Nah SY, Kim DG. · 2026-03-01
cited 2× open access unreviewed -
8
Omega-3 Fatty Acids and Alzheimer's Disease: Toward a New Understanding of Neuroprotective Mechanisms and Intervention Strategies.
Galizzi G. · 2026-06-25
cited 1× open access unreviewed -
9
Integrated lipidomic and transcriptomic profiling of the host response in human malaria.
Abdrabou W, Bolatbay D, Soulama I, Nikulkova M, Dieng MM, Zorigt S, Alshaikh M, Sermé SS, Sombié S, Henry NB,… · 2026-06-30
open access unreviewed -
10
Profiling major volatile components in apricot fruit sheds light on the molecular mechanisms underlying low-temperature-mediated volatile release.
Wang H, Sun P, Yang Y, Yu W, Kang Y, Li M, Zhou S, Sun X, Jin M, Jin W, Sun H, Wang Y. · 2026-05-09
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.