What it does, reaction by reaction
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Palmitate + CoA + ATP → palmitoyl-CoA + AMP + PPi
Converts Palmitate CoA-SH ATP into Palmitoyl-CoA AMP PPi
› Notes
An endoplasmic-reticulum/outer-mitochondrial-membrane long-chain acyl-CoA synthetase activates palmitate for elongation, desaturation, or glycerolipid synthesis. ATP is cleaved to AMP, costing two ATP equivalents.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Beta-Oxidation of Fatty Acids
Listed there as: Long-chain acyl-CoA synthetase
Fatty-acid availability; CoA and ATP
Product acyl-CoA/limited CoA at high flux
Hormones primarily regulate substrate release rather than this enzyme directly
Recent literature
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