Lipoprotein lipase (LPL) + hepatic lipase
Clinical / pharmacological. LPL or apoC-II deficiency: familial chylomicronaemia (type I), pancreatitis
What it does, reaction by reaction
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium
Chylomicron → chylomicron remnant
Converts Chylomicron into Chylomicron remnant
› Notes
Continued LPL-mediated TAG removal returns apoC-II to HDL and produces a cholesterol-enriched, apoB-48/apoE-containing remnant. Hepatic lipase can further remodel remnants. This stage does not designate one single enzyme but is a sequence of intravascular lipolysis and apolipoprotein exchange.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Autosomal dominant gain-of-function mutations in LCP1 cause a syndromic neutropenia and immunodeficiency.
Yu L, Zhou B, Liu W, Li W, Wei Q, Zhang Y, Li C, Li W, Li Y, Li G, Sun G, Gan R, Chen R, Zhang W, Zeng A, Zha… · 2026-05-12
open access unreviewed -
2
BMP-2-driven osteo-organoid formation retains key osteogenic-support features and promotes bone repair following total-body irradiation.
Zhu F, Ji L, Wang J, Liu C. · 2026-08-27
open access unreviewed -
3
Clinical considerations on the use of evinacumab for the treatment of homozygous familial hypercholesterolemia.
Bajaj A, McGuire M, Shugg S, Godin R, Underberg JA. · 2026-08-11
open access unreviewed -
4
Development and evaluation of a culturally tailored animated educational video to improve antibiotic knowledge, attitudes, and practices among Jordanian adolescents: a quasi-experimental study.
Masadeh MM, Harun SN, Mukattash TL, Alrabadi N, Alfoteih Y, Tiba B. · 2026-09-30
open access unreviewed -
5
Integrated multi-omics analysis identifies PPAR signaling network associations with metabolic-immune dysregulation and intestinal injury in PDCoV-infected piglets.
Guo X, A C, Ding Y, Zhang Y, Zhang H, Wang J, Zhang Y, Wang T. · 2026-09-27
open access unreviewed -
6
Efficacy of plasma exchange and exchange transfusion in the clinical management of severe hypertriglyceridemia in emergency.
Stefanutti C, Zeppa G, Perrone G, Labbadia G, Galoppi P, Demarco V, Fornari E, Bordugo A, Santelia C, Manciop… · 2026-09-12
open access unreviewed -
7
Targeting the gut-bone axis in osteoporosis: probiotic interventions and other microbiota-based therapeutic strategies.
Zhao K, Zhang Z, Tang Z, Man X, Liu J, Feng R, Li K, Jiang Y, Li T. · 2026-09-17
open access unreviewed -
8
Phloretin as a functional feed bioactive in livestock: Biological role, biosynthesis, and practical applications.
Areb E, Zhu Q, Han L, Pan C, Li W, Lan X. · 2026-07-25
open access unreviewed -
9
Distinct functional roles of <i>Lactobacillus</i> strains in modulating lipid metabolism, adipose accumulation, inflammatory responses, and carcass characteristics in heavy finishing pigs.
Wan B, Zeng Q, He L, Qin X, Tan M, Yan E, Liao J, Li Z, Zhang X, Yin J. · 2026-07-31
open access unreviewed -
10
Enhancement of growth performance, muscle nutrient composition, and nutritional value in rainbow trout (<i>Oncorhynchus mykiss</i>) by guanidinoacetic acid-enriched diets.
Wu D, Lu S, Li J, Zhang Y, Gao Y, Wang C, Han S, Fan Z, Li J, Liu H, Wang L. · 2026-07-31
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.