Lecithin:cholesterol acyltransferase (LCAT)
Clinical / pharmacological. LCAT deficiency: corneal opacity, anaemia, proteinuria; low HDL
What it does, reaction by reaction
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium
Free cholesterol in HDL + phosphatidylcholine → cholesteryl ester + lysophosphatidylcholine
Converts Phosphatidylcholine into Cholesteryl ester Lysophosphatidylcholine
› Notes
Lecithin:cholesterol acyltransferase (LCAT), activated by apoA-I, esterifies HDL-surface cholesterol. The cholesteryl ester moves into the hydrophobic core, converting discoidal HDL into mature spherical HDL and maintaining a gradient for additional cholesterol efflux.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Bioactive glasses-mediated ion therapy ameliorates hepatic osteodystrophy by reprogramming the liver-bone axis.
Liu SC, Xie E, Zhao P, Liu YS, Xie ZY, Chang HD, Zhao WD, Huang PY, Zhu YX, Rehman MAU, Gao Y, Urbani L, Gou … · 2026-08-31
open access unreviewed -
2
Clinical manifestations, diagnosis, and management of renal involvement in Fabry disease.
Guo W, Bi J, Ji P, Xie Y. · 2026-08-13
open access unreviewed -
3
Psychological stress-associated ceramide and diacylglyceride lipotoxicity as contributors to first-episode depression pathophysiology: A neuroimmune-metabolic-oxidative stress (NIMETOX) perspective.
Sirivatanapa V, Janta P, Almulla AF, Vasupanrajit A, Tunvirachaisakul C, Sriswasdi S, Tansawat R, Carvalho AF… · 2026-08-06
unreviewed -
4
Aggrecan and polymeric immunoglobulin receptor in extracellular vesicles of patients with seropositive rheumatoid arthritis.
Castaño-López S, Lopera TJ, Restrepo V, Carbal LF, Ramírez-Mejía JM, Hernández A, Gil D, Díaz JC, Manrique-Mo… · 2026-07-08
open access unreviewed -
5
Key protein identification in endometrium of recurrent pregnancy loss patients through integrated proteomic and transcriptomic analysis.
Huang S, Mu F, Wang K, Wang F. · 2026-04-06
unreviewed -
6
Multi-omics dissection of metabolic hijacking: Infectious bronchitis virus orchestrates lipid-centric replication through PPAR-TGF-β crosstalk.
Yan K, Wang X, Bo Z, Zhang C, Guo M, Zhang X, Wu Y. · 2026-01-28
cited 1× open access unreviewed -
7
Gypenosides Damulin A and Damulin B Inhibit Hepatocellular Carcinoma by Regulating Cholesterol Synthesis.
Li FF, Cui C, Zheng ZJ, Xiao MY, Li S, Xie P, Piao XL. · 2026-11-01
unreviewed -
8
Associations of plasma HDL subclasses with incident dementia risk in older adults.
An B, Ali S, Smith K, Roemhild S, Neumann L, Stoll DR, Li L, Lutsey PL, Mielke MM, Yu F, Hoogeveen RC, Zhang … · 2026-10-01
open access unreviewed -
9
Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity.
Park S, Park MJ, Yang HW, Park J, Yu SJ, Park SS, Choi MH, Cho EJ, Kim JH. · 2026-08-14
open access unreviewed -
10
COPI Coatomer Regulates Several Steps of HDL Metabolism.
Panteloglou G, Zanoni P, Law CS, Woods B, Othman A, Yalcinkaya M, Norrelykke SF, Rzepiela AJ, Stoma S, Steble… · 2026-08-13
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.