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unreviewed

Lecithin:cholesterol acyltransferase (LCAT)

1 reactions · 1 pathways

Clinical / pharmacological. LCAT deficiency: corneal opacity, anaemia, proteinuria; low HDL

What it does, reaction by reaction

1 reactions

Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium

step 15 Irreversible/directional

Free cholesterol in HDL + phosphatidylcholine → cholesteryl ester + lysophosphatidylcholine

Converts Phosphatidylcholine into Cholesteryl ester Lysophosphatidylcholine

› Notes

Lecithin:cholesterol acyltransferase (LCAT), activated by apoA-I, esterifies HDL-surface cholesterol. The cholesteryl ester moves into the hydrophobic core, converting discoidal HDL into mature spherical HDL and maintaining a gradient for additional cholesterol efflux.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Key protein identification in endometrium of recurrent pregnancy loss patients through integrated proteomic and transcriptomic analysis.

    Huang S, Mu F, Wang K, Wang F. · 2026-04-06

    unreviewed
  2. 2
    Multi-omics dissection of metabolic hijacking: Infectious bronchitis virus orchestrates lipid-centric replication through PPAR-TGF-β crosstalk.

    Yan K, Wang X, Bo Z, Zhang C, Guo M, Zhang X, Wu Y. · 2026-01-28

    cited 1× open access unreviewed
  3. 3
    Integrating lipidomics and network pharmacology reveals Valproic acid remodels the lipid metabolic microenvironment in hepatocellular carcinoma.

    Xu S, Ma X, Yue T, Chen Y. · 2026-07-07

    unreviewed
  4. 4
    Clinical applications of artificial intelligence-driven nitric oxide: a bibliometric and scientific mapping analysis.

    Liu Z, Abulaiti A, Zhao Y, Zang J, Li G, Shu L, Wahafu P, Yakufu M. · 2026-01-06

    open access unreviewed
  5. 5
    Psychological stress-associated ceramide and diacylglyceride lipotoxicity as contributors to first-episode depression pathophysiology: A neuroimmune-metabolic-oxidative stress (NIMETOX) perspective.

    Sirivatanapa V, Janta P, Almulla AF, Vasupanrajit A, Tunvirachaisakul C, Sriswasdi S, Tansawat R, Carvalho AF… · 2026-08-06

    unreviewed
  6. 6
    Single-cell transcriptomic insights into lipoprotein transport in yolk sac membrane endodermal epithelial cells of chicken embryos.

    Wu JC, Hu ZQ, Lin YY, Mersmann HJ, Ding ST. · 2026-04-17

    open access unreviewed
  7. 7
    Targeting ADAR1-mediated RNA editing inhibits hepatic stellate cell activation and liver fibrosis by enhancing HSC-intrinsic innate immunity.

    Xi Y, Liu L, Kim JW, Zhang M, Wang X, Abdirassil A, Xu M, Ren S, Wang Q, Yang D, Xu P, Xie W. · 2026-08-06

    unreviewed
  8. 8
    Randomized Controlled Trial of Upper Esophageal Sphincter Assist Device in Laryngopharyngeal Reflux Disease.

    Yadlapati R, Robles L, Clarke MK, Low EE, Walsh E, Krause AJ, Kaizer A. · 2025-12-22

    cited 1× open access unreviewed
  9. 9
    Extraction and UPLC-MS-MS identification of active ingredients of Henophyton deserti: Antibacterial, antifungal and in silico studies.

    Boukhalfa O, Sekkoum K, Rabia SH, Belboukhari N, Locatelli M, Malik A, Said MA, Ali I. · 2026-07-21

    unreviewed
  10. 10
    Effect of the hepatokine Tsukushi on HDL and reverse cholesterol transport.

    Lam S, Wong Y, Wing-Ming Shiu S, Lee CH, Choon-Beng Tan K. · 2026-07-20

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.