Lecithin:cholesterol acyltransferase (LCAT)
Clinical / pharmacological. LCAT deficiency: corneal opacity, anaemia, proteinuria; low HDL
What it does, reaction by reaction
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium
Free cholesterol in HDL + phosphatidylcholine → cholesteryl ester + lysophosphatidylcholine
Converts Phosphatidylcholine into Cholesteryl ester Lysophosphatidylcholine
› Notes
Lecithin:cholesterol acyltransferase (LCAT), activated by apoA-I, esterifies HDL-surface cholesterol. The cholesteryl ester moves into the hydrophobic core, converting discoidal HDL into mature spherical HDL and maintaining a gradient for additional cholesterol efflux.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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