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unreviewed

Lanosterol synthase (oxidosqualene cyclase)

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER

step 13 Irreversible/directional

(S)-2,3-Oxidosqualene → lanosterol

Converts (S)-2,3-Oxidosqualene into Lanosterol

› Notes

Lanosterol synthase (oxidosqualene cyclase) protonates and cyclizes the linear epoxide through a concerted carbocation cascade to generate the tetracyclic sterol nucleus. No ATP is directly consumed.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    <i>De novo</i> production of (-)-limonene, (-)-carveol and (-)-carvone via engineering <i>Rhodotorula toruloides</i>.

    Dong Y, Cui S, Du B, Zhang X, Hou J, Lin X, Qin Y, Wang X, Yang X. · 2026-06-13

    open access unreviewed
  2. 2
    Cost-effectiveness of pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma.

    Yu K, Xu Q. · 2026-04-15

    open access unreviewed
  3. 3
    Unlocking the "undruggable": current landscape and emerging frontiers in lysosomal receptor-mediated protein degradation.

    Ma YM, Xia HF, Xiao YL, Yu ZL. · 2026-02-25

    cited 2× open access unreviewed
  4. 4
    Identification of the first peptide inhibitor of UBE2C enzymatic activity: insights from metadynamics-guided folding and binding studies.

    Pirone L, Fiorillo B, Del Gatto A, Russo R, Guarracino A, Cassiano C, Zaccaro L, Moraca F, Pedone E, Catalano… · 2026-01-06

    open access unreviewed
  5. 5
    Facile synthesis of uniform spherical conjugated microporous polymers as stationary phases for ultra-performance liquid chromatography.

    Ni H, Wang J, Li A, Yu K, Yang G, Hu X, Sun W, Shi Q, Zhang H, Tong S. · 2026-06-05

    unreviewed
  6. 6
    Tongluo Huoxue formula reduces ligamentum flavum fibrosis in lumbar spinal stenosis.

    Chen L, Zhang W, Zhang Z, Li N, Wang L, Zheng Z, Shen H, Zhang Y. · 2026-06-16

    unreviewed
  7. 7
    8-Chloroadenosine suppresses hepatocellular carcinoma progression via ADAR1/PPARγ axis-mediated lipid metabolism.

    Liu J, Zhao Y, Gong X, Yuan L, Yang S, Jian W, Yan H, Chen H, Yang Z, Sun Y, Gu T, Lu H, Zhao H, Tu Z. · 2025-09-26

    open access unreviewed
  8. 8
    Neuroprotective effects of glucotropaeolin as the major glucosinolate of cress seed on cuprizone-induced mouse model of multiple sclerosis.

    Bathaee M, Seyedabadi M, Shokati Sayyad M, Sheidaei S, Shahani S. · 2026-06-13

    open access unreviewed
  9. 9
    Pharmacopuncture therapy versus usual care for lumbar spinal stenosis: A randomized controlled trial.

    Lee SW, Ahn YJ, Kim S, Lee Y, Cho HW, Nam D, Park Y, Kim EJ, Lee YJ, Ha IH. · 2026-03-28

    open access unreviewed
  10. 10
    Nonsurgical interventions for lumbar spinal stenosis with neurogenic claudication: A systematic review and network meta-analysis.

    Chen H, Chen X, Fang J, Wang W, Fan J, Xie Y, Lun H, Liu Z. · 2026-03-20

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.