Lanosterol synthase (oxidosqualene cyclase)
What it does, reaction by reaction
Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER
(S)-2,3-Oxidosqualene → lanosterol
Converts (S)-2,3-Oxidosqualene into Lanosterol
› Notes
Lanosterol synthase (oxidosqualene cyclase) protonates and cyclizes the linear epoxide through a concerted carbocation cascade to generate the tetracyclic sterol nucleus. No ATP is directly consumed.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Open-source modular resistance welding equipment for thermoplastic composites.
Reis JF, Barbosa Marques LF, Lucas Vieira MO, Gomes DN, Kotz TA, de Oliveira Hein LR. · 2026-09-12
open access unreviewed -
2
Plant essential oils against woody plant fungal pathogens: chemical composition, antifungal mechanisms, and translational challenges.
Alizadeh M. · 2026-09-18
open access unreviewed -
3
Early Postoperative Nutritional Management Under a Validated Diabetes-Specific Enhanced Recovery After Surgery Protocol in Patients With Lumbar Spinal Stenosis and Type 2 Diabetes Mellitus.
Chen Y, Ke B, Zhou L, Li G, Xu K, Qin H. · 2026-08-22
unreviewed -
4
TREM2 induces ligamentum flavum fibrosis by promoting TGF-β1 secretion from M2 macrophages.
Qiu J, Chen T, Zhang Y, Ge Y, Gao T, Zhang H, Lv S, Wang Z, Jiang T, Ma C, Ren Y. · 2026-08-16
unreviewed -
5
From barrier to guide: Exploiting disease-specific hemodynamics for enhanced nanodrug targeting in cardiovascular diseases.
Wang Z, Chen X, Li Y, Zhai S, Guan Z, Zhang W. · 2026-07-21
open access unreviewed -
6
<i>De novo</i> production of (-)-limonene, (-)-carveol and (-)-carvone via engineering <i>Rhodotorula toruloides</i>.
Dong Y, Cui S, Du B, Zhang X, Hou J, Lin X, Qin Y, Wang X, Yang X. · 2026-06-13
open access unreviewed -
7
The community engagement and empowerment cycle: FAIRagro's framework to foster cultural change towards FAIR RDM practices in agrosystem science and beyond.
Sennhenn A, Anderson JM, Boße S, Hoffmann C, Kirchgessner O, König M, Leroy B, Lindstädt B, Mazón ER, Sahwan … · 2026-05-18
cited 1× open access unreviewed -
8
Cost-effectiveness of pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma.
Yu K, Xu Q. · 2026-04-15
open access unreviewed -
9
Unlocking the "undruggable": current landscape and emerging frontiers in lysosomal receptor-mediated protein degradation.
Ma YM, Xia HF, Xiao YL, Yu ZL. · 2026-02-25
cited 5× open access unreviewed -
10
Identification of the first peptide inhibitor of UBE2C enzymatic activity: insights from metadynamics-guided folding and binding studies.
Pirone L, Fiorillo B, Del Gatto A, Russo R, Guarracino A, Cassiano C, Zaccaro L, Moraca F, Pedone E, Catalano… · 2026-01-06
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.