unreviewed
Lanosterol synthase (oxidosqualene cyclase)
1 reactions · 1 pathways
What it does, reaction by reaction
1 reactions
Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER
step 13
Irreversible/directional
(S)-2,3-Oxidosqualene → lanosterol
Converts (S)-2,3-Oxidosqualene into Lanosterol
› Notes
Lanosterol synthase (oxidosqualene cyclase) protonates and cyclizes the linear epoxide through a concerted carbocation cascade to generate the tetracyclic sterol nucleus. No ATP is directly consumed.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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