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unreviewed

LTA4 hydrolase; LTC4 synthase + gamma-glutamyl transpeptidase

1 reactions · 1 pathways

Cofactors used

Glutathione

What it does, reaction by reaction

1 reactions

Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane

step 5 Irreversible/directional

LTA4 -> LTB4, or LTA4 + glutathione -> LTC4 -> LTD4 -> LTE4

Converts LTA4 into LTB4, or LTA4 Glutathione (GSH)

› Notes

LTB4 is a neutrophil chemoattractant; the cysteinyl leukotrienes are the slow-reacting substance of anaphylaxis and are blocked at the receptor by montelukast/zafirlukast.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Gut microbiota in chronic inflammation: the interplay with lipid mediators.

    Bao S, Yao C. · 2026-05-06

    open access unreviewed
  2. 2
    In Vivo Effect of a Synthetic Amniotic Fluid on Fetal Lung and Gastrointestinal Tract: A Pre-Clinical Rodent Model.

    Forde B, Finoti S, Oria M, Peiro JL. · 2026-03-25

    open access unreviewed
  3. 3
    Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer.

    Soundararajan R, Maurin MM, Rodriguez-Silva J, Upadhyay G, Alden AJ, Gowda SGB, Schell MJ, Yang M, Levine NJ,… · 2025-03-06

    cited 26× open access unreviewed
  4. 4
    Pharmacogenetics of childhood uncontrolled asthma.

    Khare M, Piparia S, Tantisira KG. · 2023-05-19

    cited 1× unreviewed
  5. 5
    Acid-base Homeostasis and Implications to the Phenotypic Behaviors of Cancer.

    Zhou Y, Chang W, Lu X, Wang J, Zhang C, Xu Y. · 2022-07-01

    cited 13× open access unreviewed
  6. 6
    ESICM LIVES 2023.

    · 2023-10-24

    cited 2× open access unreviewed
  7. 7
    How Is Arachidonic Acid Metabolism in the Uterus Connected with the Immune Status of Red Deer Females (<i>Cervus elaphus</i> L.) in Different Reproductive Stages?

    Kotlarczyk AM, Kaczmarczyk J, Witkowska-Piłaszewicz O, Kotula-Balak M, Korzekwa AJ. · 2023-03-01

    cited 1× open access unreviewed
  8. 8
    Knock-out of 5-lipoxygenase in overexpressing tumor cells-consequences on gene expression and cellular function.

    Weisser H, Göbel T, Melissa Krishnathas G, Kreiß M, Angioni C, Sürün D, Thomas D, Schmid T, Häfner AK, Kahnt … · 2022-09-16

    cited 12× open access unreviewed
  9. 9
    LTA4H rs2660845 association with montelukast response in early and late-onset asthma.

    Maroteau C, Espuela-Ortiz A, Herrera-Luis E, Srinivasan S, Carr F, Tavendale R, Wilson K, Hernandez-Pacheco N… · 2021-09-22

    cited 9× open access unreviewed
  10. 10
    Recent updates on the role of extracellular vesicles in the pathogenesis of allergic asthma.

    Srinivasan A, Sundar IK. · 2021-05-12

    cited 19× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.