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unreviewed

LTA4 hydrolase; LTC4 synthase + gamma-glutamyl transpeptidase

1 reactions · 1 pathways

Cofactors used

Glutathione

What it does, reaction by reaction

1 reactions

Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane

step 5 Irreversible/directional

LTA4 -> LTB4, or LTA4 + glutathione -> LTC4 -> LTD4 -> LTE4

Converts LTA4 into LTB4, or LTA4 Glutathione (GSH)

› Notes

LTB4 is a neutrophil chemoattractant; the cysteinyl leukotrienes are the slow-reacting substance of anaphylaxis and are blocked at the receptor by montelukast/zafirlukast.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Gut microbiota in chronic inflammation: the interplay with lipid mediators.

    Bao S, Yao C. · 2026-05-06

    open access unreviewed
  2. 2
    Multi-Omics Profiling of High-Grade Serous Ovarian Cancer Reveals an Inflammation-Related Lipid Metabolism Subtype Associated With Platinum Resistance.

    Zhao Y, Li J, Zheng B, Liu W, Wang Y, Wang S, Cui Y, Guo H, Wang H, Xiao T, Qian K, Zuo J. · 2026-07-17

    open access unreviewed
  3. 3
    In Vivo Effect of a Synthetic Amniotic Fluid on Fetal Lung and Gastrointestinal Tract: A Pre-Clinical Rodent Model.

    Forde B, Finoti S, Oria M, Peiro JL. · 2026-03-25

    open access unreviewed
  4. 4
    Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer.

    Soundararajan R, Maurin MM, Rodriguez-Silva J, Upadhyay G, Alden AJ, Gowda SGB, Schell MJ, Yang M, Levine NJ,… · 2025-03-06

    cited 26× open access unreviewed
  5. 5
    Pharmacogenetics of childhood uncontrolled asthma.

    Khare M, Piparia S, Tantisira KG. · 2023-05-19

    cited 1× unreviewed
  6. 6
    Acid-base Homeostasis and Implications to the Phenotypic Behaviors of Cancer.

    Zhou Y, Chang W, Lu X, Wang J, Zhang C, Xu Y. · 2022-07-01

    cited 14× open access unreviewed
  7. 7
    ESICM LIVES 2023.

    · 2023-10-24

    cited 3× open access unreviewed
  8. 8
    How Is Arachidonic Acid Metabolism in the Uterus Connected with the Immune Status of Red Deer Females (<i>Cervus elaphus</i> L.) in Different Reproductive Stages?

    Kotlarczyk AM, Kaczmarczyk J, Witkowska-Piłaszewicz O, Kotula-Balak M, Korzekwa AJ. · 2023-03-01

    cited 1× open access unreviewed
  9. 9
    Knock-out of 5-lipoxygenase in overexpressing tumor cells-consequences on gene expression and cellular function.

    Weisser H, Göbel T, Melissa Krishnathas G, Kreiß M, Angioni C, Sürün D, Thomas D, Schmid T, Häfner AK, Kahnt … · 2022-09-16

    cited 12× open access unreviewed
  10. 10
    LTA4H rs2660845 association with montelukast response in early and late-onset asthma.

    Maroteau C, Espuela-Ortiz A, Herrera-Luis E, Srinivasan S, Carr F, Tavendale R, Wilson K, Hernandez-Pacheco N… · 2021-09-22

    cited 10× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.