unreviewed
LTA4 hydrolase; LTC4 synthase + gamma-glutamyl transpeptidase
1 reactions · 1 pathways
Cofactors used
What it does, reaction by reaction
1 reactions
Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane
step 5
Irreversible/directional
LTA4 -> LTB4, or LTA4 + glutathione -> LTC4 -> LTD4 -> LTE4
Converts LTA4 into LTB4, or LTA4 Glutathione (GSH)
› Notes
LTB4 is a neutrophil chemoattractant; the cysteinyl leukotrienes are the slow-reacting substance of anaphylaxis and are blocked at the receptor by montelukast/zafirlukast.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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