L-3-hydroxyacyl-CoA dehydrogenase
Cofactors used
Clinical / pharmacological. MCAD deficiency: hypoketotic hypoglycaemia, dicarboxylic aciduria, SIDS-like presentation
What it does, reaction by reaction
Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)
L-3-Hydroxyacyl-CoA + NAD+ → 3-ketoacyl-CoA + NADH + H+
Converts L-3-Hydroxyacyl-CoA NAD+ into 3-Ketoacyl-CoA NADH H+
› Notes
L-3-hydroxyacyl-CoA dehydrogenase oxidizes the β-hydroxyl group using NAD+. NADH donates electrons to complex I of the respiratory chain.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Mechanisms of Serotonergic Modulation of Glial Cell Functions in the Recovery Period After Spinal Cord Injury.
Nikiforova EV, Vetlugina A, Konovalova SP, Sysoev YI, Musienko PE. · 2026-09-15
open access unreviewed -
2
Structure-Function Relationships of Unusual Fatty Acids with Distinctive Functional Group Modifications and Carbon Chain Skeletons: Focus on the Roles of Double Bonds and Methyl Branches in Metabolism and Signaling.
Li Y, Luo L, Song K, Huang X, Peng M, Chen F, Wang Z. · 2026-07-28
open access unreviewed -
3
Apabetalone Drives a Metabolic Shift Towards Ketogenesis and Reduces Liver Steatosis in Diet-Induced Obesity Mice.
Tsujikawa LM, Carestia A, Wasiak S, Sarsons CD, Jahagirdar R, Azhar S, Gilham D, Li D, Fu L, Johansson JO, Wo… · 2026-07-22
open access unreviewed -
4
Disrupting Treg lineage stability elicits RORgT-mediated plasticity and enhances anti-tumor immunity.
Swain CA, Hinshaw DC, Miranda ID, Metge BJ, Elhamamsy A, Chen D, Lee A, Guo H, Papineni B, Williams L, Rathme… · 2026-07-06
open access unreviewed -
5
The inhibitors of 17β-HSD10: are they any good?
Kwa E, Ogilvie CE, Kormos NC, Green AJE, Smith TK, Gunn-Moore FJ. · 2026-05-28
open access unreviewed -
6
Downregulated ECHS1 and HADH-mediated fatty acid β-oxidation contributes to mitochondrial dysfunction in salivary glands of Sjögren's syndrome.
Zhou M, Liu Y, He J, Li C, Wu B. · 2026-01-11
open access unreviewed -
7
Integrated multi-omics analysis reveals a lipid-redox regulatory network underlying drought tolerance and yield stability in rice.
Hai R, Chen X, Gao Y, Lu S, Wang X, Xu X, Zhou W, Duan R, Jiang G, Liu J. · 2026-05-27
cited 1× open access unreviewed -
8
Integrated spatial multi-omics delineates fatty acid degradation fuels malignant evolution at the tumour periphery in cervical squamous cell carcinoma.
Lin S, Luo Z, Li Y, Hu B, Qu M, Liu B, Cao C, Peng T, Xu M, Xu Y, Liu X, Wang X, Li L, Ding W, Xu Z, Li R, Zh… · 2026-04-27
cited 1× open access unreviewed -
9
Benchmarking genetic birth prevalence estimates against newborn screening data.
Sierant MC, Knoblauch N, Witt E, Gaffney D, Pulit SL, Wuster A. · 2026-04-24
open access unreviewed -
10
Fatty acid metabolic reprogramming in the tumor microenvironment: Unraveling mechanisms and therapeutic prospects.
Zhang W, Wang P, Yuan G, Liu F, Jin G, Zhang J. · 2025-07-14
cited 7× open access unreviewed
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