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unreviewed

ACAT1 / ACAT2

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium

step 13 Irreversible/directional

Cellular cholesterol feedback: free cholesterol → storage and reduced synthesis/uptake

Converts Free cholesterol

› Notes

ACAT1/ACAT2 esterify excess intracellular cholesterol for storage. Cholesterol suppresses SREBP-2 activation, reduces HMG-CoA reductase and LDLR transcription, and promotes HMG-CoA reductase degradation. Macrophage uptake of modified LDL through scavenger receptors (e.g., SR-A and CD36) is not feedback down-regulated and promotes foam-cell formation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    A Subset of Caveolin-1 Interacts with a Fraction of Acyl-CoA:Cholesterol Acyltransferase 1 (ACAT1/SOAT1) at an Endoplasmic Reticulum Subdomain to Attenuate Cholesteryl Ester Biosynthesis

    Chang C, Fujimoto T, Yamauchi Y, Urano Y, Chang T. · 2026-06-01

    open access unreviewed
  2. 2
    Identification of Foxm1 as a critical regulator for metabolic dysfunction-associated steatotic liver disease by epigenomic and transcriptional profiling.

    Zeng C, Wei M, Li H, Niu F, Guo Z, Li LY, Wu M, Chen MK. · 2026-04-14

    open access unreviewed
  3. 3
    Seipin-defined ER sites undergo distinct enrichment of factors for the biogenesis of sterol ester rich lipid droplets.

    Khatri A, Yadav S, Hashmi U, Dandriyal AK, Choudhary V. · 2026-04-08

    open access unreviewed
  4. 4
    Tides of Promise: Sponge-Derived Marine Natural Products in Southeast Asia

    Tan L, Widyantoro C, Hanif N. · 2026-03-01

    open access unreviewed
  5. 5
    Live-Cell Imaging and Lipidomics of Low-Density Lipoprotein Containing Intrinsically Fluorescent Cholesteryl Esters.

    Juhl AD, Sprenger RR, Modzel M, Halder S, Szomek M, Akkerman V, Xu Y, Heegaard CW, Ejsing CS, Covey DF, Wüstn… · 2026-02-26

    open access unreviewed
  6. 6
    Citicoline Triggers Proteome Remodeling and Proteostatic Adaptation: Evidence from Shotgun Proteomics.

    Cavaterra D, Giammaria S, Pandino I, Zingale GA, Delli Paoli V, Fiore R, Michelessi M, Roberti G, Carnevale C… · 2026-01-01

    open access unreviewed
  7. 7
    Zearalenone exposure may increase the risk of non-alcoholic fatty liver disease by activating CYP1B1-SCD1.

    Ruan H, Zhang J, Wang Y, Zhang D, Luo J, Yang M. · 2025-12-13

    open access unreviewed
  8. 8
    Dietary restriction reprograms CD8<sup>+</sup> T cell fate to enhance anti-tumour immunity and immunotherapy responses.

    Oswald BM, DeCamp LM, Longo J, Dahabieh MS, Bunda N, Johnson BK, Watson MJ, Ma S, Preston SEJ, Sheldon RD, Vi… · 2025-12-09

    cited 12× open access unreviewed
  9. 9
    PPARγ mediated enhanced lipid biogenesis fuels <i>Mycobacterium tuberculosis</i> growth in a drug-tolerant hepatocyte environment.

    Sarkar B, Singh J, Yadav M, Sharma P, Sharma RD, Singh S, Chandramouli A, Mehdiratta K, Kumar A, Kamat SS, Gh… · 2025-12-08

    cited 4× open access unreviewed
  10. 10
    The Potential Therapeutic Applications of Natural Products in the Oxidative Stress-Related MVA Pathway: Focus on HMGCR.

    Teng YN. · 2025-08-16

    cited 1× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.