Skip to content
MS
Sign in
unreviewed

ACAT1 / ACAT2

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium

step 13 Irreversible/directional

Cellular cholesterol feedback: free cholesterol → storage and reduced synthesis/uptake

Converts Free cholesterol

› Notes

ACAT1/ACAT2 esterify excess intracellular cholesterol for storage. Cholesterol suppresses SREBP-2 activation, reduces HMG-CoA reductase and LDLR transcription, and promotes HMG-CoA reductase degradation. Macrophage uptake of modified LDL through scavenger receptors (e.g., SR-A and CD36) is not feedback down-regulated and promotes foam-cell formation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Refresh

Europe PMC · fetched just now · sorted by publication date

  1. 1
    Circadian reprogramming of inflammation and metabolism in chronic kidney disease.

    Li XQ, Cheng L, Chen TF, Ma YN, Li XH, Fu TY, Xiao J, Zhao ZZ. · 2026-09-06

    open access unreviewed
  2. 2
    Divergent mechanistic reliance on the phosphatidylinositol 4-kinase (PI4K)/oxysterol-binding protein (OSBP) axis during Zika virus versus dengue virus and West Nile virus replication organelle biogenesis.

    Ahmad S. · 2026-09-27

    unreviewed
  3. 3
    Binaphthoquinone attenuates myofibroblast transition of human ventricular cardiac fibroblasts <i>in vitro via</i> mitochondrial modulation under diabetic conditions.

    Yoon CS, Ko JR, Park N, Park SH, Kim HK, Han J. · 2026-05-20

    open access unreviewed
  4. 4
    Phospholipid remodeling as a key regulator of ferroptosis.

    Shingaki T, Aoki J, Kono N. · 2026-06-25

    cited 1× open access unreviewed
  5. 5
    The Plant Growth Regulator Forchlorfenuron (KT-30) Drives Atherosclerosis Progression via Lipid Homeostasis Disruption: Evidence from ApoE-Deficient Mice.

    Chen CH, Hu PA, Chuang CS, Chen WH, Tang HY, Hsu CP, Lee TS. · 2026-07-30

    open access unreviewed
  6. 6
    Metabolomic and transcriptomic landscape of the bovine uterine lumen during the second week of the estrous cycle.

    Waheed A, Rocha CC, Bastien AB, Maldonado MBC, Ashrafi N, Mimi RA, Graham SF, Peñagaricano F, Binelli M. · 2026-07-09

    open access unreviewed
  7. 7
    Systemic immunosuppression limits NK cell therapy efficacy in pancreatic cancer.

    He C, Wang D, Hu T, Gonzalez D, Thakur R, Matysniak DP, King RJ, Kollala SS, Markov SD, Fujii Y, Tej GNVC, Zh… · 2026-07-08

    cited 1× open access unreviewed
  8. 8
    A Subset of Caveolin-1 Interacts with a Fraction of Acyl-CoA:Cholesterol Acyltransferase 1 (ACAT1/SOAT1) at an Endoplasmic Reticulum Subdomain to Attenuate Cholesteryl Ester Biosynthesis.

    Chang CCY, Fujimoto T, Yamauchi Y, Urano Y, Chang TY. · 2026-06-08

    open access unreviewed
  9. 9
    Identification of Foxm1 as a critical regulator for metabolic dysfunction-associated steatotic liver disease by epigenomic and transcriptional profiling.

    Zeng C, Wei M, Li H, Niu F, Guo Z, Li LY, Wu M, Chen MK. · 2026-04-14

    open access unreviewed
  10. 10
    Seipin-defined ER sites undergo distinct enrichment of factors for the biogenesis of sterol ester rich lipid droplets.

    Khatri A, Yadav S, Hashmi U, Dandriyal AK, Choudhary V. · 2026-04-08

    cited 1× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.