ACAT1 / ACAT2
What it does, reaction by reaction
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium
Cellular cholesterol feedback: free cholesterol → storage and reduced synthesis/uptake
Converts Free cholesterol
› Notes
ACAT1/ACAT2 esterify excess intracellular cholesterol for storage. Cholesterol suppresses SREBP-2 activation, reduces HMG-CoA reductase and LDLR transcription, and promotes HMG-CoA reductase degradation. Macrophage uptake of modified LDL through scavenger receptors (e.g., SR-A and CD36) is not feedback down-regulated and promotes foam-cell formation.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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