unreviewed

Homogentisate 1,2-dioxygenase (HGD)

1 reactions · 1 pathways

Cofactors used

Fe2+ · Iron O2

Clinical / pharmacological. Alkaptonuria: dark urine on standing, ochronosis, arthritis

What it does, reaction by reaction

1 reactions

Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion

step 12 Irreversible/directional

Homogentisate + O₂ → maleylacetoacetate

Converts Homogentisate O2 into Maleylacetoacetate

› Notes

Homogentisate 1,2-dioxygenase opens the aromatic ring using Fe²⁺. Deficiency blocks this reaction and causes alkaptonuria.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

1
A Step-Up Underwater Endoscopic Mucosal Resection Strategy with Rescue Underwater Injection Endoscopic Mucosal Resection for Non-Pedunculated Colorectal Lesions.
Yoshida A, Ono T, Ito S, Watanabe K, Okuzono T, Iijima K. · 2026-05-06

open access unreviewed
2
Robust decoding for MI-EEG: a hybrid transformer network using multi-perspective collaborative attention and dynamic hyperbolic tangent.
Wang M, Gong Z, Li Y, Li Y, Zheng Y. · 2026-05-16

unreviewed
3
A machine-learning informed circulating microbial DNA signature for early diagnosis of esophageal adenocarcinoma.
Li Y, Xu C, Park H, Omstead AN, Anees M, Sherry C, Khan AF, Grayhack E, Weksler B, Wagner P, Bartlett DL, Mel… · 2025-12-24

open access unreviewed
4
Cancer Risk After Initial Surveillance of Intraductal Papillary Mucinous Neoplasms (IPMNs): Are We Missing the Window for Prevention?
Pea A, Dall'Olio T, Solinas D, Filippini C, Venturini E, De Pastena M, Luchini C, Crinò S, Zamboni GA, D'Onof… · 2026-06-09

cited 1× unreviewed
5
Barriers and enablers to initiating and maintaining positive dietary changes during and after pregnancy-A qualitative study of participants in the Healthy Gut Diet Study.
O'Connor H, Wilkinson SA, Meloncelli N, Rushton A, de Jersey S. · 2026-09-01

unreviewed
6
Sediment heterogeneity drives divergent arsenic transformation pathways through organic matter-microbial coupling in aquifers.
Li E, Xie X, Zhang Y, Yan L, Wang Y. · 2026-08-05

unreviewed
7
Nonconventional colorectal dysplasia is less prevalent and has a more limited morphologic spectrum in patients without inflammatory bowel disease.
Law T, Wang D, Lauwers GY, Choi WT. · 2026-08-04

unreviewed
8
Liver transplantation in primary sclerosing cholangitis with hepatobiliary neoplasia: survival outcomes and impact of diagnostic uncertainty.
Breder S, Wang B, Villard C, Båve A, Lindström-Älgå L, Eide E, Engesæter LK, Reims HM, Grzyb K, Aabakken L, M… · 2026-08-04

unreviewed
9
Plummer-Vinson syndrome in a 10-year-old boy from Côte d'Ivoire: An exceptional paediatric case with African context.
Tayou Mbobda PM, Kouamé HGD, Ouattara A. · 2026-08-03

unreviewed
10
Eliminating circulating donor passenger leukocytes during clinical ex vivo lung perfusion does not attenuate inflammation.
Hu MA, Zhang ZL, Hoffmann RF, Gan CT, Verschuuren EAM, Van De Wauwer C, Leuvenink HGD, Erasmus ME. · 2026-07-06

unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.