Homogentisate 1,2-dioxygenase (HGD)
Cofactors used
Clinical / pharmacological. Alkaptonuria: dark urine on standing, ochronosis, arthritis
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Homogentisate + O₂ → maleylacetoacetate
Converts Homogentisate O2 into Maleylacetoacetate
› Notes
Homogentisate 1,2-dioxygenase opens the aromatic ring using Fe²⁺. Deficiency blocks this reaction and causes alkaptonuria.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Flushing-Assisted Saline Immersion Endoscopic Submucosal Dissection in the Rectum: A Video-Based Feasibility Series.
Matthews T, Landy J, Ban H, Toyonaga T, Suzuki N. · 2026-09-30
open access unreviewed -
2
Cold Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors: Current Evidence and Clinical Perspectives.
Mikuriya Y, Takizawa K, Minakata N, Shiotsuki K. · 2026-09-07
open access unreviewed -
3
A Step-Up Underwater Endoscopic Mucosal Resection Strategy with Rescue Underwater Injection Endoscopic Mucosal Resection for Non-Pedunculated Colorectal Lesions.
Yoshida A, Ono T, Ito S, Watanabe K, Okuzono T, Iijima K. · 2026-05-06
open access unreviewed -
4
Mentha-mediated selenium nanoparticles attenuate adriamycin-induced chronic kidney disease via multi-target modulation of oxidative, inflammatory, and fibrotic pathways.
Abdelaziz AE, Shokeir AA, Awad BI, Awadalla A, Abdelghany AM, El-Khawaga OY. · 2026-09-16
open access unreviewed -
5
Robust decoding for MI-EEG: a hybrid transformer network using multi-perspective collaborative attention and dynamic hyperbolic tangent.
Wang M, Gong Z, Li Y, Li Y, Zheng Y. · 2026-05-16
unreviewed -
6
A machine-learning informed circulating microbial DNA signature for early diagnosis of esophageal adenocarcinoma.
Li Y, Xu C, Park H, Omstead AN, Anees M, Sherry C, Khan AF, Grayhack E, Weksler B, Wagner P, Bartlett DL, Mel… · 2025-12-24
cited 4× open access unreviewed -
7
Compartment-Specific Immunohistochemical Alterations Along the Colorectal Adenoma-Carcinoma Continuum.
Özcan TB, Erel E, Pasaoglu E. · 2026-08-17
unreviewed -
8
Sediment heterogeneity drives divergent arsenic transformation pathways through organic matter-microbial coupling in aquifers.
Li E, Xie X, Zhang Y, Yan L, Wang Y. · 2026-08-05
unreviewed -
9
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
Miyamoto K, Sakai S, Endo M, Terigele, Niibori M, Morita T, Goto Y, Yoshida A, Tanaka T, Lin N, Kuchimaru T, … · 2026-10-05
open access unreviewed -
10
The role of vitamin D signalling in β cell apoptosis: a systematic review.
Li D, Norris N, An Y, Gunton JE. · 2026-10-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.