Histidine decarboxylase (HDC)
Cofactors used
What it does, reaction by reaction
Other Neurotransmitter Synthesis Amino Acid & Nitrogen Metabolism · Cytosol
L-Histidine -> histamine + CO2
Converts Histidine into Histamine CO2
› Notes
Stored in mast cells and basophils; degraded by diamine oxidase and histamine N-methyltransferase.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Promiscuous activity of ornithine decarboxylase from Enterobacter hormaechei: An alternative pathway for histamine formation in fermented sausages.
He W, Li B, Hu K, Zhong X, Zhang Y, Yu J, Xie J, Li C, Li F, Wu L, Li S, Li J, Hu X, Ao X, Hui T, Zhao N, Liu… · 2026-07-23
unreviewed -
2
DSN : Energy-efficient EMG signal classification method enabling real-time monitoring for edge healthcare.
Zhang Z, Meng X, Wei J, Zeng M, Zeng Z. · 2026-06-29
unreviewed -
3
Biodegradable molybdenum intramedullary nails facilitate fracture repair through neutrophil-mediated immune response.
Zhu C, He Y, Zhao Y, Huang Y, Zhang C, Zhou J, Liang H, Qin H, Fang Z, Liu D, Dai J, Li P, Qian J. · 2026-09-01
open access unreviewed -
4
<i>In vivo</i> porcine multi-omics integration identifies microbiome-driven histamine elevation and lasting gut perturbations following <i>Ascaris suum</i> infection and fenbendazole treatment.
Liu F, Streett H, Solano-Aguilar G, Smith AD, Carbaugh D, Urban JF, Li RW. · 2026-09-11
open access unreviewed -
5
Single-cell RNA sequencing uncovers an immunosuppressive program in PDAC mast cells: tumour-driven activation, proliferation, and association with Treg recruitment.
Wu M, Ye X, Yu Q, Huang H, Zhang Z, Yu X, Lou S, Xu J. · 2026-08-31
open access unreviewed -
6
Design, synthesis, and stability evaluation of semaglutide-derived lactam-stapled peptide scaffolds for GLP-1R targeting.
Liu T, Ren X, Li Y, Wang J, Chen J, Lin R, Zhang J. · 2026-08-11
open access unreviewed -
7
Colonic nutritional and physicochemical parameters drive gut microbiota dysbiosis in obesity: what we learned from the Ob-M-ARCOL model development.
Uriot O, Deschamps C, Etienne-Mesmin L, Brun M, Pouget M, Chalancon S, Durif C, Chaudemanche C, Alric M, Boir… · 2026-06-09
open access unreviewed -
8
CRISPR/Cas9 mediates precise and efficient gene editing in <i>Xanthomonas oryzae</i> pv. <i>oryzae</i>.
Luo Y, Sun S, Xi JJ. · 2026-04-27
open access unreviewed -
9
Integrating bulk and single-cell transcriptomic data to construct a risk model for histidine metabolism-related epithelial cell features in lung adenocarcinoma, predicting prognosis and immune landscape.
Mao C, Zhou L. · 2026-04-28
cited 1× open access unreviewed -
10
Aging-caused the changes of the gut microbiota drive intestinal barrier dysfunction and increase sepsis susceptibility.
Liang H, Ding X, Liu S, Tong S, Wang X, Zhang Z, Wang W, Zhang X, Yuan Y, Jiang Y, Sun T. · 2026-02-21
cited 3× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.