unreviewed
Hepatic lipase / LDLR / LRP1
1 reactions · 1 pathways
What it does, reaction by reaction
1 reactions
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium
step 11
Irreversible/directional
IDL → hepatic uptake or LDL
Converts IDL
› Notes
ApoE-containing IDL can be cleared by hepatic LDLR/LRP1. Alternatively, hepatic lipase hydrolyzes residual TAG and phospholipid, apoE is lost, and the particle is remodeled to cholesteryl-ester-rich LDL, which contains apoB-100 as its sole major apolipoprotein.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
No articles returned.