ABCA1 (cholesterol/phospholipid efflux transporter)
What it does, reaction by reaction
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium
ApoA-I + phospholipid → nascent discoidal HDL
Converts ApoA-I Phospholipid into Nascent discoidal HDL
› Notes
Liver and intestine secrete lipid-poor apoA-I. Peripheral-cell cholesterol and phospholipid are exported to apoA-I via ABCA1, forming nascent discoidal HDL; ABCA1 activity is induced by liver X receptor (LXR) in response to cellular oxysterols.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Glucagon-like peptide-1: a critical link between gut microbiota dysbiosis and degenerative musculoskeletal diseases.
Yang W, Hao C, Wang N, Xie J, Zhou B, Yang Z, Zheng A, Wei J, Li C, Xie C, Li H, Lei G, Zeng C. · 2026-04-22
open access unreviewed -
2
Diethyl Phthalate (DEP) as a potential osteosarcoma risk factor: a multi-omics study integrating network Toxicology, single-cell RNA sequencing, and molecular docking.
Yin S, Liu W, Gao C, Li C, Wu J. · 2026-02-16
open access unreviewed -
3
lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes.
Fu C, Lan S, Lin Y, Chen D, Yang Z, Chen C, Chen Y, Yuan Y, Zhong W, Lin Q, Huang Z. · 2026-02-12
open access unreviewed -
4
Mitochondrial dysfunction and applications of mitochondrial-targeted delivery systems in atherosclerosis.
Liu Y, Luo N, Xi X, Hou J, Li X, Xia M, Yu T, Yang Y, Liu Y. · 2026-02-10
open access unreviewed -
5
Immunometabolic transcriptomic signatures of diabetes-related genes predict kidney transplant rejection.
Casale R, Dello Strologo A, Alfieri C, Grandaliano G, Pesce F. · 2026-02-09
open access unreviewed -
6
Targeting mitochondrial quality control in diabetic kidney disease: emerging therapeutic opportunities.
Luo J, Lu F, Cuciureanu M, Xu X, Dong H, Gong M. · 2026-02-03
cited 2× open access unreviewed -
7
Imbalance of mitochondria and abnormalities in lipid metabolism in Diabetic Tubulopathy.
Sun C, Li Y, Tao Y, Wu Q, Liu B, Zhou Y. · 2026-01-18
open access unreviewed -
8
Probiotic extracellular vesicles reprogram macrophage immunometabolism: From gut crosstalk to host health.
Li Y, Liu Y, Wei X, Wang C, Zahoor Khan M, Ma Q. · 2026-01-11
cited 2× open access unreviewed -
9
cAMP-PKA/EPAC signaling pathways: crucial regulators of lipid homeostasis.
Chen C, Gao H, Tian Q, Cao J. · 2026-01-07
open access unreviewed -
10
<b>Gut‒heart axis: emerging therapies targeting trimethylamine</b> <b>N-oxide production</b>.
Torres ER, Wilcox J, Tang WHW. · 2025-12-27
cited 3× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.