ABCA1 (cholesterol/phospholipid efflux transporter)
What it does, reaction by reaction
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium
ApoA-I + phospholipid → nascent discoidal HDL
Converts ApoA-I Phospholipid into Nascent discoidal HDL
› Notes
Liver and intestine secrete lipid-poor apoA-I. Peripheral-cell cholesterol and phospholipid are exported to apoA-I via ABCA1, forming nascent discoidal HDL; ABCA1 activity is induced by liver X receptor (LXR) in response to cellular oxysterols.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
A dual-targeting mRNA lipid nanoparticle restores ABCA1-dependent cholesterol homeostasis to promote repair of age-related bone defects.
Cheng M, Xi K, Ni Z, Wang L, Tang J, Wang W, Li Z, Zhou L, Jiang X, Wu J, Guo Q, Zhu Y, Tao Z, Li T, Cui C, C… · 2026-08-20
open access unreviewed -
2
MERTK-related engulfment of norepinephrinergic neuronal presynaptic membrane by astrocytes following acute TBI and potentiation effect of peripheral nerve modulation.
Liao X, Li M, Niu F, Zhao Z, Hong J, Deng Y, Yan Y, He C, Liao Y, Li R, Zhuang Y, Gao G. · 2026-09-27
open access unreviewed -
3
Lipid droplets as redox-active organelles after spinal cord injury: lipid peroxidation, mitochondrial dysfunction, and neuroinflammation.
Zhang Y, Li J, Liu Y, Guo D. · 2026-08-19
open access unreviewed -
4
Multi-omics study of ABCA1 in sepsis: Integrating mendelian randomisation, single-cell transcriptomics, in silico knockout and virtual screening.
Yu Y, Zhang S. · 2026-08-07
unreviewed -
5
Posttraumatic stress disorder is associated with Alzheimer's disease-relevant molecular alterations in the basolateral amygdala of older Veterans.
Seijo MA, Yohannes PA, Rogers AL, Gonzalez JC, Banerjee A, Kelley H, Pierce M, McQuail JA, Hernandez CM. · 2026-07-22
unreviewed -
6
Bis-(di-4-phenyl-benzylaminethiocarbonyl)disulfide sensitizes ABCC2/ALDH3A1 overexpressing NSCLC cells to cisplatin.
Kryczka J, Kryczka JM, Janczewski Ł, Shimida S, Frączyk A, Kolesińska B, Boncela J, Brzeziańska-Lasota E. · 2026-07-20
open access unreviewed -
7
New insights into the ACLY-mediated metabolic and epigenetic interplay in macrophages.
Yuan L, Wang T, Song Y, Guo P, Zhu Y, Cao Y, Song B, Yu Z. · 2026-06-25
open access unreviewed -
8
Glucagon-like peptide-1: a critical link between gut microbiota dysbiosis and degenerative musculoskeletal diseases.
Yang W, Hao C, Wang N, Xie J, Zhou B, Yang Z, Zheng A, Wei J, Li C, Xie C, Li H, Lei G, Zeng C. · 2026-04-22
open access unreviewed -
9
Diethyl Phthalate (DEP) as a potential osteosarcoma risk factor: a multi-omics study integrating network Toxicology, single-cell RNA sequencing, and molecular docking.
Yin S, Liu W, Gao C, Li C, Wu J. · 2026-02-16
cited 1× open access unreviewed -
10
lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes.
Fu C, Lan S, Lin Y, Chen D, Yang Z, Chen C, Chen Y, Yuan Y, Zhong W, Lin Q, Huang Z. · 2026-02-12
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.