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unreviewed

ABCA1 (cholesterol/phospholipid efflux transporter)

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium

step 14 Irreversible/directional

ApoA-I + phospholipid → nascent discoidal HDL

Converts ApoA-I Phospholipid into Nascent discoidal HDL

› Notes

Liver and intestine secrete lipid-poor apoA-I. Peripheral-cell cholesterol and phospholipid are exported to apoA-I via ABCA1, forming nascent discoidal HDL; ABCA1 activity is induced by liver X receptor (LXR) in response to cellular oxysterols.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Glucagon-like peptide-1: a critical link between gut microbiota dysbiosis and degenerative musculoskeletal diseases.

    Yang W, Hao C, Wang N, Xie J, Zhou B, Yang Z, Zheng A, Wei J, Li C, Xie C, Li H, Lei G, Zeng C. · 2026-04-22

    open access unreviewed
  2. 2
    Diethyl Phthalate (DEP) as a potential osteosarcoma risk factor: a multi-omics study integrating network Toxicology, single-cell RNA sequencing, and molecular docking.

    Yin S, Liu W, Gao C, Li C, Wu J. · 2026-02-16

    open access unreviewed
  3. 3
    lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes.

    Fu C, Lan S, Lin Y, Chen D, Yang Z, Chen C, Chen Y, Yuan Y, Zhong W, Lin Q, Huang Z. · 2026-02-12

    open access unreviewed
  4. 4
    Mitochondrial dysfunction and applications of mitochondrial-targeted delivery systems in atherosclerosis.

    Liu Y, Luo N, Xi X, Hou J, Li X, Xia M, Yu T, Yang Y, Liu Y. · 2026-02-10

    open access unreviewed
  5. 5
    Immunometabolic transcriptomic signatures of diabetes-related genes predict kidney transplant rejection.

    Casale R, Dello Strologo A, Alfieri C, Grandaliano G, Pesce F. · 2026-02-09

    open access unreviewed
  6. 6
    Targeting mitochondrial quality control in diabetic kidney disease: emerging therapeutic opportunities.

    Luo J, Lu F, Cuciureanu M, Xu X, Dong H, Gong M. · 2026-02-03

    cited 2× open access unreviewed
  7. 7
    Imbalance of mitochondria and abnormalities in lipid metabolism in Diabetic Tubulopathy.

    Sun C, Li Y, Tao Y, Wu Q, Liu B, Zhou Y. · 2026-01-18

    open access unreviewed
  8. 8
    Probiotic extracellular vesicles reprogram macrophage immunometabolism: From gut crosstalk to host health.

    Li Y, Liu Y, Wei X, Wang C, Zahoor Khan M, Ma Q. · 2026-01-11

    cited 2× open access unreviewed
  9. 9
    cAMP-PKA/EPAC signaling pathways: crucial regulators of lipid homeostasis.

    Chen C, Gao H, Tian Q, Cao J. · 2026-01-07

    open access unreviewed
  10. 10
    <b>Gut‒heart axis: emerging therapies targeting trimethylamine</b> <b>N-oxide production</b>.

    Torres ER, Wilcox J, Tang WHW. · 2025-12-27

    cited 3× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.