ABCA1 (cholesterol/phospholipid efflux transporter)
What it does, reaction by reaction
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium
ApoA-I + phospholipid → nascent discoidal HDL
Converts ApoA-I Phospholipid into Nascent discoidal HDL
› Notes
Liver and intestine secrete lipid-poor apoA-I. Peripheral-cell cholesterol and phospholipid are exported to apoA-I via ABCA1, forming nascent discoidal HDL; ABCA1 activity is induced by liver X receptor (LXR) in response to cellular oxysterols.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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