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unreviewed

Glycogen branching enzyme (GBE1; 4:6 transferase)

1 reactions · 1 pathways

Clinical / pharmacological. Andersen disease (GSD IV): polyglucosan, cirrhosis

What it does, reaction by reaction

1 reactions

Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism · Cytosol (glycogen particle)

step 6 Irreversible/directional

An alpha(1→4)-linked chain segment → alpha(1→6)-branched glycogen

Converts An alpha(1→4)-linked chain segment into Alpha(1→6)-branched glycogen

› Notes

The glycogen branching enzyme (amylo-alpha(1,4)→alpha(1,6)-transglycosylase; 4:6 transferase) transfers a terminal block of roughly 6–7 residues from a sufficiently long chain to the C6 hydroxyl of an internal glucose residue. It creates an alpha(1→6) branch at least several residues away from another branch, increasing solubility and the number of nonreducing ends for future synthesis and degradation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Glycogenesis (Glycogen Synthesis)

Listed there as: Glycogen branching enzyme

Accelerated by

Adequate elongated alpha(1→4) chains

Inhibited by

—

Hormonal control

No dominant acute hormonal regulation; expression influences branching architecture

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Glycogen and Glycosylation: Friends or Foes?

    Konada R, Osborn J, Mitra S. · 2026-06-01

    open access unreviewed
  2. 2
    Arthrogryposis Multiplex Congenita: Comprehensive Review from a Neuromuscular Standpoint

    Seneor D, Barile J, Mendes P, Orsini M, da Silva E, Farias I, Serrano P, Pinto W, Oliveira A, de Souza P. · 2026-06-01

    open access unreviewed
  3. 3
    Abstract

    · 2026-06-01

    unreviewed
  4. 4
    Integrative Advances in Equine Genomics From Reference Assemblies to Evolutionary History and Key Traits.

    Lu Y, Ma R, Wang B, Wu J, Chong Y, Gao Z, Deng W. · 2026-06-17

    open access unreviewed
  5. 5
    AKAP1 enhances glycogen accumulation and hepatocarcinogenesis through YTHDF2-mediated G6PC mRNA decay.

    Yang T, Zhang J, Zhao Z, Cheng S, Yan Z, Wang W, Wang G, Zhang R, Zhang Z, Yuan P, Zheng X, Zhang H, Li J, Xi… · 2026-06-16

    open access unreviewed
  6. 6
    Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets.

    Li C, Liu Z, Kong D, Li Z, Yan Y, Dong Y, Zhu L, Cao J, Fan Z, Sethi G, Li L. · 2026-06-08

    open access unreviewed
  7. 7
    Single-cell identifies and validates human circulating Treg subtype/state Treg<sup>fci</sup> in non-small cell lung cancer.

    Liu X, Liu Y, Duan W, Weng J, Dai H, Liu F, Wang L, Qian M, Zhu B, Wu S, Ye Y, Yuan M, Hong S, Wang M, Cheng … · 2026-06-03

    cited 1× open access unreviewed
  8. 8
    Genome-wide association analysis to identify novel candidate genes and genomic model optimization to predict acute low-temperature stress resilience in olive flounder (Paralichthys olivaceus).

    Hanchapola HACR, Kim G, Omeka WKM, Gong P, Liyanage DS, Udayantha HMV, Kodagoda YK, Dilshan MAH, Rodrigo DCG,… · 2026-02-05

    unreviewed
  9. 9
    Integrated Transcriptomic and Metabolomic Analyses Reveal Adaptive Mechanisms of <i>Medicago sativa</i> Under Water Stress.

    Song Y, Niu N, Wu Y, Huo Q, Qu Y, Xi L. · 2026-05-16

    open access unreviewed
  10. 10
    Ultra-rare variants in LAMA2 are risk factors for frontotemporal dementia and motor neuron disease.

    Lok HC, Dobson-Stone C, Hallupp M, Matis S, Landin-Romero R, Guennewig B, Mundell H, Don AS, Fifita J, McCann… · 2026-05-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.