Glycogen branching enzyme (GBE1; 4:6 transferase)
Clinical / pharmacological. Andersen disease (GSD IV): polyglucosan, cirrhosis
What it does, reaction by reaction
Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism · Cytosol (glycogen particle)
An alpha(1→4)-linked chain segment → alpha(1→6)-branched glycogen
Converts An alpha(1→4)-linked chain segment into Alpha(1→6)-branched glycogen
› Notes
The glycogen branching enzyme (amylo-alpha(1,4)→alpha(1,6)-transglycosylase; 4:6 transferase) transfers a terminal block of roughly 6–7 residues from a sufficiently long chain to the C6 hydroxyl of an internal glucose residue. It creates an alpha(1→6) branch at least several residues away from another branch, increasing solubility and the number of nonreducing ends for future synthesis and degradation.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Glycogenesis (Glycogen Synthesis)
Listed there as: Glycogen branching enzyme
Adequate elongated alpha(1→4) chains
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No dominant acute hormonal regulation; expression influences branching architecture
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Identification of rare maternal copy number variants by genome-wide analysis of noninvasive prenatal screening data in 113,017 pregnant women.
Hu L, Cao X, Zeng S, Wen L, Zhong J, Liu Y, Liu W, Wei F. · 2026-09-09
open access unreviewed -
2
Identifying regulatory muscle processes in infantile and adult Pompe patients using a multi‐omic and morphological approach
Schaiter A, Lohanadan K, Mensch A, Hentschel A, Rosenbohm A, Kornblum C, Roth A, Procida‐Kowalski T, Krämer H… · 2026-10-07
open access unreviewed -
3
Comparative RNA-Seq and Phytochemical Profiling Reveal Year-Dependent Bioactive Variations and Delineate Key Metabolic Pathways in <i>Polygonatum sibiricum</i> Red. Rhizome Nodes.
Li C, Su X, Yang Y, Cao Y, Li L, Lu D, Sun Y, Wang L, Su M, Yu Y, Lu H, Tan Z, Liang H. · 2026-09-17
open access unreviewed -
4
Omics Studies in Osteoarthritis: A Review of Molecular Mechanisms and Candidate Molecules.
Sun Y, Xiao Q, Jin M, Liu G, Zhang Q, Wei X. · 2026-09-18
open access unreviewed -
5
Transcriptome Analysis Reveals a Potential Response Mechanism of <i>Morchella</i> to Soybean Meal Addition.
Yue Y, Wang Q, Zhang Y, Xiao T, Hao H, Tong Z, Li W, Huang J, Zhang J, Chen H. · 2026-09-02
open access unreviewed -
6
Adaptive responses to fractionated feeding: transient hyperphagia and reversible hepatic lipid deposition in mule ducks.
Zwick LL, Szczepaniak R, Coustaut K, Galbadrakh T, Lasserre M, Fericelli Y, Ricaud K, Biasutti S, Gontier K, … · 2026-09-16
open access unreviewed -
7
Assessing the therapeutic potential of PDE-5 inhibitors in adults: Insights from a multi-omics study.
McGovern KA, Wright TJ, Marchant ED, Kilroe SP, Durham WJ, Dillon EL, Baum MM, Kinsky MP, Russell WK, Fry CS,… · 2026-09-01
open access unreviewed -
8
Integrative Physiological and Transcriptomic Analyses of Oat (<i>Avena sativa</i> L.) Seedlings Under Severe Salt Stress.
Qiu R, Zhang X, Kong X, Zhao W, Zhao Q, Chu Y, Tuluohong M, Wang B, Cui G, Li B. · 2026-09-03
open access unreviewed -
9
Mechanisms of formic acid stress response in evolved yeast for microbial-electrocatalytic systems.
Liu J, Bi W, Liu M, Wang S, Wu X, Hou J, Xu Y. · 2026-08-10
open access unreviewed -
10
RNA-Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities.
Li L, Yan X, Ji Q, Zhang H. · 2026-08-24
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.