Glycogen branching enzyme (GBE1; 4:6 transferase)
Clinical / pharmacological. Andersen disease (GSD IV): polyglucosan, cirrhosis
What it does, reaction by reaction
Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism · Cytosol (glycogen particle)
An alpha(1→4)-linked chain segment → alpha(1→6)-branched glycogen
Converts An alpha(1→4)-linked chain segment into Alpha(1→6)-branched glycogen
› Notes
The glycogen branching enzyme (amylo-alpha(1,4)→alpha(1,6)-transglycosylase; 4:6 transferase) transfers a terminal block of roughly 6–7 residues from a sufficiently long chain to the C6 hydroxyl of an internal glucose residue. It creates an alpha(1→6) branch at least several residues away from another branch, increasing solubility and the number of nonreducing ends for future synthesis and degradation.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Glycogenesis (Glycogen Synthesis)
Listed there as: Glycogen branching enzyme
Adequate elongated alpha(1→4) chains
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No dominant acute hormonal regulation; expression influences branching architecture
Recent literature
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