Glycerol-3-phosphate acyltransferase (GPAT)
Cofactors used
What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
Glycerol-3-phosphate + fatty acyl-CoA → lysophosphatidic acid (1-acyl-glycerol-3-phosphate) + CoA-SH
Converts Glycerol-3-phosphate Fatty acyl-CoA into Lysophosphatidic acid CoA-SH
› Notes
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first acylation, usually at sn-1. This is an important regulatory/committing step of the glycerol-3-phosphate pathway.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Breed-specific meat quality and flavor characteristics of Wannan and Chinese Simmental cattle revealed by whole transcriptome and metabolome analysis.
Song N, Wang J, Meng X, Cui S, Jin S, Tang H, Zhang Y, Liu H. · 2026-09-01
open access unreviewed -
2
Calcium overload-induced apoptosis in cancer cells: ER-mitochondria crosstalk and therapeutic implications.
Ding Y, Liu X, Xue J, Fu J, Liu S, Xu X, Jiao X, Wu Z, Yang G, Wang H, Zhang P. · 2026-06-22
open access unreviewed -
3
Integrated transcriptome and metabolome reveal <i>Mycoplasma hyopneumoniae</i> -induced lipid accumulation, inflammation, oxidative stress, and energy imbalance in the liver of pigs.
Xue X, Bu Y, Yu C, Li J, Yang J, Gao M, Wang P, Gan Y, Zhang W, Fan S, Zhou R, Yin Z, Zheng X. · 2026-06-03
cited 1× open access unreviewed -
4
Genetics of MASLD: a diabetes perspective.
Bilson J, Yaghootkar H. · 2026-06-08
cited 3× open access unreviewed -
5
MASLD, diabetes and PMOS across the female life stages.
Stener-Victorin E, Carlsson S, Hagström H, Taebnia N. · 2026-06-05
cited 2× open access unreviewed -
6
Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies.
Zhao Y, Xu W, Wang Y, Huang H, Su Y, Zhou L, Liu J, Guo J. · 2026-10-02
open access unreviewed -
7
Paternal DHA supplementation before conception shapes offspring lipid metabolism in a sex- and postnatal diet-dependent manner.
Quynh DD, García-Santillán JA, Van Thuan N, Bolaños-Jiménez F. · 2026-08-15
unreviewed -
8
Inhibition of Acetylation Activity of p300/CBP Ameliorates Hepatic Steatosis Through Downregulation of ACSL4.
Cai LY, Guan YP, Hu JH, Sun CY, Ding CH, Zhang X, Zeng X, Xie WF. · 2026-10-01
cited 1× unreviewed -
9
Convergent evolution of metabolic regulation governs redox adaptation in Toxoplasma.
Giuliano CJ, Kalluraya CA, Kloehn J, Sloan MA, Bunkofske ME, Hunter CA, Soldati-Favre D, Harding CR, Lourido … · 2026-08-11
unreviewed -
10
Genome-wide study uncovering the role of GPAT gene family in watermelon and functional validation of ClGPAT8 against cold stress.
Aslam A, Wang X, Waseem M, Azam M, Masroor A, Shi Q, Muhammad S, Smerat A, Razzaq MK, Zhang R. · 2026-06-22
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.