Glycerol-3-phosphate acyltransferase (GPAT)
Cofactors used
What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
Glycerol-3-phosphate + fatty acyl-CoA → lysophosphatidic acid (1-acyl-glycerol-3-phosphate) + CoA-SH
Converts Glycerol-3-phosphate Fatty acyl-CoA into Lysophosphatidic acid CoA-SH
› Notes
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first acylation, usually at sn-1. This is an important regulatory/committing step of the glycerol-3-phosphate pathway.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
-
1
Integrated transcriptome and metabolome reveal <i>Mycoplasma hyopneumoniae</i> -induced lipid accumulation, inflammation, oxidative stress, and energy imbalance in the liver of pigs.
Xue X, Bu Y, Yu C, Li J, Yang J, Gao M, Wang P, Gan Y, Zhang W, Fan S, Zhou R, Yin Z, Zheng X. · 2026-06-03
open access unreviewed -
2
Genome-wide study uncovering the role of GPAT gene family in watermelon and functional validation of ClGPAT8 against cold stress.
Aslam A, Wang X, Waseem M, Azam M, Masroor A, Shi Q, Muhammad S, Smerat A, Razzaq MK, Zhang R. · 2026-06-22
unreviewed -
3
A Cross-Species Single-Cell Transcriptomic Atlas of Subcutaneous Adipose Tissue Reveals Conserved and Divergent Cellular Programs.
Niu X, Zhai L, Wang L, Wang J, Zheng Z, Yang J, Wang X, Liu J, Xing K, Wang C. · 2026-08-01
unreviewed -
4
Improving incretin-mediated body weight loss via energy expenditure.
Elmendorf AJ, Douros JD, Knerr PJ, Flak JN. · 2026-03-27
unreviewed -
5
Hybrid transcriptome sequencing uncovers widespread shifts in transcript usage between mid-lactation and dry-off in goats.
Cardoso TF, Wang M, Noce A, Luigi-Sierra M, Martínez A, Delgado-Bermejo JV, Salama AAK, Such FX, Jordana J, A… · 2026-07-27
unreviewed -
6
Changes in palmitate- and stearate-containing glycerophospholipids in skeletal muscle during clenbuterol-induced fast-twitch fiber transition and hypertrophy.
Suzuki Y, Sato T, Ohuchi S, Nakashima S, Miyoshi N, Miura S. · 2026-05-21
open access unreviewed -
7
<i>Ganoderma lucidum</i> polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice.
Jin X, Liu X, Wang YJ, Lei ZL, Yang YH. · 2026-05-22
cited 1× open access unreviewed -
8
Redundant Glycerol-3-Phosphate Acyltransferases Regulate Thermo-Sensitive Genic Male Sterility in Rice.
Cheng S, Zheng H, Tian Y, Wang C, Yu X, Dong K, Wang J, Lu J, Chen K, He X, Shao K, Gao J, Yao B, Hu Y, Xie Z… · 2026-04-01
open access unreviewed -
9
Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis.
Liu XZ, Panina Y, Panina Y, Cai W, Fernández-García J, Peng-Winkler Y, Mao J, Dahlhaus A, Zhou HC, Liu M, Pla… · 2026-07-01
open access unreviewed -
10
Genetic and Genomic Insights Across the SLD Spectrum.
Mann JP, Wijarnpreecha K, Prasitsumrit V, Trépo E, Speliotes EK, Chen VL. · 2026-06-29
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.