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unreviewed

Glycerol kinase + glycerol-3-phosphate dehydrogenase (hepatic)

1 reactions · 1 pathways

Cofactors used

ATP

What it does, reaction by reaction

1 reactions

Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER

step 11 Reversible

Glycerol + ATP → glycerol-3-phosphate + ADP; glycerol-3-phosphate ⇌ DHAP

Converts Glycerol ATP into Glycerol-3-phosphate ADP

› Notes

Hepatic glycerol kinase and glycerol-3-phosphate dehydrogenase metabolize adipose-derived glycerol. These downstream reactions permit glycerol carbon to enter gluconeogenesis or glycolysis during fasting.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency.

    Tiwari V, Jin B, Sun O, Lopez Gonzalez EDJ, Chen MH, Wu X, Shah H, Zhang A, Herman MA, Spracklen CN, Goodman … · 2025-11-14

    cited 11× open access unreviewed
  2. 2
    Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics.

    Ma X, Huang T, Chen X, Li Q, Liao M, Fu L, Huang J, Yuan K, Wang Z, Zeng Y. · 2025-02-08

    cited 64× open access unreviewed
  3. 3
    Aquaporin-9 facilitates liver regeneration following hepatectomy.

    Zhang B, Lv D, Chen Y, Nie W, Jiao Y, Zhang J, Zhou X, Wu X, Chen S, Ma T. · 2022-01-22

    cited 26× open access unreviewed
  4. 4
    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms.

    Sostre-Colón J, Uehara K, Garcia Whitlock AE, Gavin MJ, Ishibashi J, Potthoff MJ, Seale P, Titchenell PM. · 2021-05-01

    cited 26× open access unreviewed
  5. 5
    Toward an understanding of the protein interaction network of the human liver.

    Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, Chen H, Jin C, Wei J, Zhang W, Yang… · 2011-10-11

    cited 196× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.