What it does, reaction by reaction
Glutathione Metabolism (gamma-Glutamyl Cycle) Amino Acid & Nitrogen Metabolism · Cytosol
gamma-Glutamylcysteine + glycine + ATP -> glutathione (GSH) + ADP + Pi
Converts gamma-Glutamylcysteine Glycine ATP into Glutathione (GSH) ADP Pi
› Notes
Deficiency causes 5-oxoprolinuria (pyroglutamic aciduria) with haemolytic anaemia.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
The RNA binding protein ZFP36L2 displays tissue-selective mRNA targeting in mice.
Stephenson GS, Fleifel D, Cook JG, Laederach A, Ramos SBV. · 2026-06-21
open access unreviewed -
2
Significance of GSH and H<sub>2</sub>S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health.
Majumder A, Majumder S, Bano S, Sen K, Nayak KB. · 2026-06-11
open access unreviewed -
3
The double-edged nature of antibody bivalency: mathematical and experimental analysis of cell surface antigen occupancy and opsonization.
Heirene L, Lodge J, Fedorova M, Gauntlett R, Cordy J, Rattray Z, Byrne H, Gaffney E, Yates JWT. · 2026-06-03
open access unreviewed -
4
Sauchinone attenuates UVB-induced photoaging by suppressing oxidative stress and ferroptosis through activation of the Keap1-Nrf2 pathway in dermal fibroblasts.
Zhang X, Wang J, Zhou Y, Shen C, Yuan M, Li Q, Li W. · 2026-05-21
open access unreviewed -
5
Influence of sound vibrations on plant holobionts: physiological pathways linking root function and rhizospheric microbial interactions.
Naeem HK, Comparini D, Bighignoli B, Mozzo G, Yamashita F, Renna L, Stefano G, Mancuso S, Masi E. · 2026-04-15
open access unreviewed -
6
Epidemiology and phylogenomic characterization of the Clade IIb C.1 Mpox outbreak in Phnom Penh, Cambodia (2023-2024).
Nouhin J, Jansen D, Nay T, Chin S, Dantas PHLF, Pum L, Khun L, Mov C, Pho S, Keo S, Kruy L, Lim R, Chel K, Ch… · 2026-03-10
open access unreviewed -
7
Assessing changes in academic motivation across medical training stages: a longitudinal study in Malaysia.
Aziz CR, Mohd Noor MN, Ibrahim MF, Lin GSS, Azhary JMK, Lye AJ, Vadivelu J, Foong CC. · 2026-01-12
open access unreviewed -
8
The therapeutic potential of targeting LYAR in gastric cancer.
Qin K, Chen GQ, Ling JW, Li YF, Li Q, Li DM, Li B, Li JD, Wu KJ, He RQ, Qin DY, Dang YW, Chen G, Tang YL. · 2026-01-09
open access unreviewed -
9
Ginsenosides alleviate the progression of hepatic fibrosis by targeting the liver circadian clock gene <i>CLOCK</i>.
Yu J, Qian C, Que R, Zhou Y. · 2026-07-31
unreviewed -
10
Lactiplantibacillus plantarum LP15-1 alleviates deoxynivalenol-induced intestinal injury in mice by inhibiting ferroptosis and modulating the gut microbiota.
Teng K, Li J, He B, Song D, Duan T, Liu K, Qiao L, Li A, Wang W, Fan S. · 2026-06-10
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.