What it does, reaction by reaction
Glutathione Metabolism (gamma-Glutamyl Cycle) Amino Acid & Nitrogen Metabolism · Cytosol
gamma-Glutamylcysteine + glycine + ATP -> glutathione (GSH) + ADP + Pi
Converts gamma-Glutamylcysteine Glycine ATP into Glutathione (GSH) ADP Pi
› Notes
Deficiency causes 5-oxoprolinuria (pyroglutamic aciduria) with haemolytic anaemia.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.
Kong D, Duan R, Wang X, Wang X, Zhao J. · 2026-09-18
open access unreviewed -
2
Seasonal affective disorder among medical students in Sudan: A cross-sectional study of prevalence and seasonal patterns.
Alrayah MAF, Bashir MMI. · 2026-09-14
unreviewed -
3
Foliar GR24 and γ-aminobutyric acid modulate redox signaling, root-system architecture, and mineral homeostasis in tellurite-stressed wheat (<i>Triticum aestivum</i> L.).
Haider I, Rehman SU, Iqbal Z, Mahmood A, Zaheer A, Nadeem MY, Mubushar M, Tahir MU. · 2026-09-11
open access unreviewed -
4
Genetic overlap between estimated glomerular filtration rate and cardiovascular disease identifies potential targets for cardiorenal syndrome.
Li W, Chen Y, Xiong W, Yuan S. · 2026-08-27
open access unreviewed -
5
Ferroptosis: significance to zoonotic diseases and therapeutic prospects.
Tian L, Cheng X, Ni J, Yang R, Ouyang W, Qi T, Liu Q, Wang D, Chen H, Wang X. · 2026-08-25
open access unreviewed -
6
An Open-Source, Reproducible MRI Data Acquisition and Reconstruction Workflow Using Pulseq: Multi-Site and Cross-Vendor Validation.
Chen Q, Roos THM, Murguia A, Xie Y, Liu Z, Xu P, Fujita S, Littin S, Rathi Y, Zhu J, Bilgic B, Nielsen JF, Za… · 2026-08-06
open access unreviewed -
7
Multi-omics integration deciphers arsenic-induced multi-organ toxicity and the novel ferroptosis axis.
Zhang X. · 2026-07-04
open access unreviewed -
8
The RNA binding protein ZFP36L2 displays tissue-selective mRNA targeting in mice.
Stephenson GS, Fleifel D, Cook JG, Laederach A, Ramos SBV. · 2026-06-21
open access unreviewed -
9
Significance of GSH and H<sub>2</sub>S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health.
Majumder A, Majumder S, Bano S, Sen K, Nayak KB. · 2026-06-11
open access unreviewed -
10
The double-edged nature of antibody bivalency: mathematical and experimental analysis of cell surface antigen occupancy and opsonization.
Heirene L, Lodge J, Fedorova M, Gauntlett R, Cordy J, Rattray Z, Byrne H, Gaffney E, Yates JWT. · 2026-06-03
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.