Glutathione peroxidase (GPX)
Cofactors used
Clinical / pharmacological. Selenium-dependent; principal RBC peroxide defence
What it does, reaction by reaction
Glutathione Metabolism (gamma-Glutamyl Cycle) Amino Acid & Nitrogen Metabolism · Cytosol
2 GSH + H2O2 -> GSSG + 2 H2O
Converts Glutathione (GSH) H2O2 into GSSG (oxidised glutathione) H2O
› Notes
Selenocysteine enzyme; the principal peroxide defence of the erythrocyte.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Reassigning an amber codon to selenocysteine using a functional cysteine suppression pair in <i>Escherichia coli</i>.
Niu S, Wei J, Li M, Guo B, Yan Q, Huang Y, Jiang Z, Song J. · 2026-07-29
unreviewed -
2
Oxidative stress, depressive symptoms, disability, cognitive outcomes and hand dexterity in relapsing-remitting multiple sclerosis patients with mild/moderate disability.
Mosaddeghi-Heris R, Taheri N, Talebi M, Naseri A. · 2026-07-31
unreviewed -
3
Protective effect of Glycyrrhizin on cuprizone-induced model of multiple sclerosis in male C57BL/6 mice.
Morakkabi AS, Hassanpour S, Hosseini R. · 2026-07-28
unreviewed -
4
Microbiota-liver axis and host transcriptomic mechanisms underlying the anti-obesity effects of Bifidobacterium animalis DPU-MWFBA in early-life overfeeding.
Gao Z, Zhao B, Mu G, Nie H, Wu X. · 2026-06-27
unreviewed -
5
Plasma membrane H<sup>+</sup>-ATPase Pma1 regulates growth and virulence in Penicillium digitatum from citrus fruits involving iron homeostasis.
Lin X, Kang H, Yang S, Fan G, Peng L, Mu H, Wang Y. · 2026-06-26
unreviewed -
6
Hesperidin mitigates cognitive and anxiety-like deficits by enhancing hippocampal antioxidant defenses, reducing neuroinflammation, and preventing neuronal apoptosis in a third-trimester-equivalent rat model of developmental ethanol neurotoxicity.
Jamali Z, Mohseni F, Salimi A, Garmabi B, Khaksari M. · 2026-06-05
open access unreviewed -
7
Nanozymes: bridging nanoscale characteristics and catalytic mechanisms for advanced biomedical applications.
Sun Y, Yang Y, Kang X, Wang Y. · 2026-06-22
open access unreviewed -
8
Research progress of ferroptosis in gynecological diseases.
Chen W, Zhou W, Liu S. · 2026-06-19
open access unreviewed -
9
Synergistic application of taurine and spermidine enhances wheat tolerance to neodymium stress through redox homeostasis, metabolic adjustment, and nutrient regulation.
Iqbal R, Mehmood H, Majeed A, Murtaza G, Rebouh NY, Alotaibi MS, Alotaibi SS, Ullah S, Huseynova A, Ali S. · 2026-06-15
open access unreviewed -
10
Significance of GSH and H<sub>2</sub>S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health.
Majumder A, Majumder S, Bano S, Sen K, Nayak KB. · 2026-06-11
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.