Glutathione peroxidase (GPX)
Cofactors used
Clinical / pharmacological. Selenium-dependent; principal RBC peroxide defence
What it does, reaction by reaction
Glutathione Metabolism (gamma-Glutamyl Cycle) Amino Acid & Nitrogen Metabolism · Cytosol
2 GSH + H2O2 -> GSSG + 2 H2O
Converts Glutathione (GSH) H2O2 into GSSG (oxidised glutathione) H2O
› Notes
Selenocysteine enzyme; the principal peroxide defence of the erythrocyte.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Reassigning an amber codon to selenocysteine using a functional cysteine suppression pair in <i>Escherichia coli</i>.
Niu S, Wei J, Li M, Guo B, Yan Q, Huang Y, Jiang Z, Song J. · 2026-07-29
open access unreviewed -
2
Multienzymatic hybrid bio-heterojunction for synergistic microenvironment reprogramming and selenoprotein-activated mitochondrial bioenergetics in diabetic osseointegration.
Zhang M, Lu M, Chen Y, Ming M, Luo B, Wu Y. · 2026-09-16
open access unreviewed -
3
Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction.
Jiang Y, Li H, Wang W, Guo Q, Wang C, Li Y, Lu H, Chen J, Yang H, Zhao X, Zheng L, Qiao Y. · 2026-09-03
open access unreviewed -
4
A logic-gated nanoplatform spatiotemporally orchestrates immunometabolic reprogramming and osteogenesis for diabetic periodontal regeneration.
Jiang Y, Liu S, Li X, Han L, Liu H, Li M. · 2026-09-04
open access unreviewed -
5
An oral coral-like resveratrol nanocomplex protects against dry eye disease through ocular and systemic redox homeostasis.
Cui Q, Li Y, Xie M, Liu Z, Guo Y, Zang Y, Bao J, Wu Q, Tian L, Jie Y. · 2026-09-04
open access unreviewed -
6
PXDN knockdown alleviates hepatic stellate cell activation by regulating GPX1.
Ren G, Zhou W, Li Y, Zhang X, Li L. · 2026-09-10
unreviewed -
7
ROS-responsive H<sub>2</sub>S-releasing quaternized chitosan dental implant coating for improved soft tissue integration, antibacterial and immunomodulatory capacities.
Xie Y, Xia D, Chen Z, Wu H, Zeng L, Zhong T, Chen W, Du X, Ma M, Yang X. · 2026-08-20
open access unreviewed -
8
A universal consuming endogenous H<sub>2</sub>S strategy using bismuth-metal-organic nanocapsule networks for overcoming osteosarcoma cisplatin resistance.
Lin Y, Yuan K, Liu Y, Du Y, Chang H, Hou L, Liang Y, Huang K, Yang S, Tang T. · 2026-08-18
open access unreviewed -
9
Melatonin reduces intestinal oxidative damage in broilers with pulmonary hypertension under high-altitude and cold stress.
Bahadoran S, Torabi AH, Hassanpour H. · 2026-09-19
open access unreviewed -
10
Nonlinear dose-response evaluation of RenalMax supplementation in broiler chickens.
Asghari-Moghadam M, Behboodi HR, Mehri M. · 2026-08-15
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.