Skip to content
MS
Sign in
unreviewed

Glutathione S-transferase (GST)

2 reactions · 2 pathways

Cofactors used

Glutathione GSH

Clinical / pharmacological. Conjugates NAPQI; depletion underlies paracetamol hepatotoxicity

What it does, reaction by reaction

2 reactions

Glutathione Metabolism (gamma-Glutamyl Cycle) Amino Acid & Nitrogen Metabolism · Cytosol

step 5 Irreversible/directional

Xenobiotic/electrophile + GSH -> GS-conjugate -> mercapturic acid

Converts Xenobiotic/electrophile Glutathione (GSH) into GS-conjugate

› Notes

Phase II conjugation; depletion of GSH by NAPQI underlies paracetamol (acetaminophen) hepatotoxicity, treated with N-acetylcysteine.

Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER

step 3 Irreversible/directional

Electrophile + GSH -> GS-conjugate -> mercapturic acid

Converts Glutathione (GSH) into GS-conjugate

› Notes

Detoxifies reactive intermediates such as NAPQI from paracetamol.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Refresh

Europe PMC · fetched just now · sorted by publication date

  1. 1
    <i>C1orf127</i> deficiency causes cardiac abnormalities by disrupting the regulation of transcription initiation and interactions with RNA-binding proteins.

    Chen Y, Yao C, Yu K, Wu B, Zhang Y, Zhou X. · 2026-02-23

    open access unreviewed
  2. 2
    Dismantling the eDNA-mediated H&lt;sub&gt;2&lt;/sub&gt;S barrier with biohybrids against refractory biofilm infections.

    Yin M, Su M, Yi J, Ren Y, Zhang Y, Wu Q, Yang C, Xiao S, Gao C, Tang R, Cheng B, Xia J. · 2026-09-15

    open access unreviewed
  3. 3
    &lt;i&gt;Lactiplantibacillus plantarum&lt;/i&gt; as a multifunctional probiotic for inflammatory bowel disease: Mechanisms, synbiotic strategies, and delivery systems.

    Tao W, Liu W, Shi X, Han S, Shen Y, Sun W, Sha Y, Wang G, Chen Y, Ying H. · 2026-07-10

    open access unreviewed
  4. 4
    LC-ESI-MS/MS and HPLC analysis and larvicidal activity of Retama sphaerocarpa hydro-ethanolic extract against mosquito vectors of diseases (Culiseta longiareolata).

    Seghier H, Guenez R, Bouabida H, Ben Moussa MT, Dris D. · 2026-07-01

    unreviewed
  5. 5
    VCP at the crossroads of UPS and autophagy in cancer.

    Hitchman CJ, Phillips JI, Park HW, Lu H. · 2026-05-28

    open access unreviewed
  6. 6
    The DDIT4L-TOM40-ATP5A pathway suppresses glioblastoma oncogenesis.

    You P, Qi ZX, Luo H, Cai B, Hu XY, Pan J, Gan PP, Zeng XY, Liao RJ, Tang Q, Yu Y, Zhang ZN, Yang B, Chen L, Z… · 2026-03-04

    open access unreviewed
  7. 7
    Facilely fabricating fluorescent iron-doped polymer dots nanozyme with oxidase-like activity for dual-mode analysis of glutathione S-transferase and its inhibitor.

    Wang L, Liu W, Qiu D, Zhang G, Zhao Y. · 2026-08-01

    unreviewed
  8. 8
    Structure-guided discovery of novel ERα-binding peptides with in vitro antiproliferative activity.

    Guo T, Zhang Y, Yang S, Yang L, Chen Q, Wang Y, Dou R, Yuan D. · 2026-10-01

    open access unreviewed
  9. 9
    Tropical vulnerability and temperate resilience: molecular and physiological insights into cold stress adaptation in oil palm.

    Wu Q, Imran M, Chen G, Zeng X, Zhou L. · 2026-09-29

    open access unreviewed
  10. 10
    Identification of Crocin I as a positive modulator of GSTP1 with potential relevance to prostate cancer.

    Qin H, Wang Y, Yang Y, Fang H, Li Y, Yang Y, Xiong Y, Zhang L. · 2026-09-28

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.