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unreviewed

Glutathione S-transferase (GST)

2 reactions · 2 pathways

Cofactors used

Glutathione GSH

Clinical / pharmacological. Conjugates NAPQI; depletion underlies paracetamol hepatotoxicity

What it does, reaction by reaction

2 reactions

Glutathione Metabolism (gamma-Glutamyl Cycle) Amino Acid & Nitrogen Metabolism · Cytosol

step 5 Irreversible/directional

Xenobiotic/electrophile + GSH -> GS-conjugate -> mercapturic acid

Converts Xenobiotic/electrophile Glutathione (GSH) into GS-conjugate

› Notes

Phase II conjugation; depletion of GSH by NAPQI underlies paracetamol (acetaminophen) hepatotoxicity, treated with N-acetylcysteine.

Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER

step 3 Irreversible/directional

Electrophile + GSH -> GS-conjugate -> mercapturic acid

Converts Glutathione (GSH) into GS-conjugate

› Notes

Detoxifies reactive intermediates such as NAPQI from paracetamol.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    USP14 promotes head and neck squamous cell carcinoma progression via deubiquitinating and stabilizing CFL2.

    Liu Y, Wang Z, Liu W, Li P, Chen J, Shi Z, Ye J. · 2026-07-15

    unreviewed
  2. 2
    Plasma membrane H<sup>+</sup>-ATPase Pma1 regulates growth and virulence in Penicillium digitatum from citrus fruits involving iron homeostasis.

    Lin X, Kang H, Yang S, Fan G, Peng L, Mu H, Wang Y. · 2026-06-26

    unreviewed
  3. 3
    Kaempferol from <i>Moringa oleifera</i> L. increases longevity and ameliorates efavirenz-induced functional senescence in <i>Drosophila melanogaster</i>.

    Iorjiim WM, Makwin LL, Ipav SS, Omale S. · 2026-06-25

    unreviewed
  4. 4
    Guilu Erxian oral liquid alleviates oligoasthenospermia via the mitochondria-complement-NETs network.

    Yue Q, Tong K, Feng Q, Chang H, Zhang Z, Xu X, Pan T, Xu Z, Chen L, Liu J, Liu Z. · 2026-06-25

    unreviewed
  5. 5
    Hesperidin mitigates cognitive and anxiety-like deficits by enhancing hippocampal antioxidant defenses, reducing neuroinflammation, and preventing neuronal apoptosis in a third-trimester-equivalent rat model of developmental ethanol neurotoxicity.

    Jamali Z, Mohseni F, Salimi A, Garmabi B, Khaksari M. · 2026-06-05

    open access unreviewed
  6. 6
    Metabolic engineering of <i>Saccharomyces cerevisiae</i> for co-production of ergothioneine, salidroside and gadusol.

    Zhang L, Xiao S, Wang D, Zhang P, Xu R, Hu L, Kang Z. · 2026-06-10

    open access unreviewed
  7. 7
    Nao-xin-tong capsule attenuates cerebral ischemia/reperfusion injury by modulating the p53/GDF15/NOX4 regulatory network and alleviating mitochondrial dysfunction and ferroptosis-related injury.

    Jiao J, Shang J, Yan M, Wang B, Wei W, Cui Y, Zhang J, Liu X. · 2026-06-18

    unreviewed
  8. 8
    Significance of GSH and H<sub>2</sub>S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health.

    Majumder A, Majumder S, Bano S, Sen K, Nayak KB. · 2026-06-11

    open access unreviewed
  9. 9
    Research progress on the role of host factors in Chikungunya virus infection and intervention strategies.

    Chen Y, Zhang K, Qi Z, Ding C. · 2026-05-27

    open access unreviewed
  10. 10
    Protective effects of <i>Angelica dahurica</i> polysaccharide on oxidative stress and liver injury induced by ovariectomized/D-galactose in rats.

    He XQ, Li YZ, Xu LB, Wu CF, Wei DD, Liu HY, Qiu F. · 2026-05-20

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.