Glutathione S-transferase (GST)
Cofactors used
Clinical / pharmacological. Conjugates NAPQI; depletion underlies paracetamol hepatotoxicity
What it does, reaction by reaction
Glutathione Metabolism (gamma-Glutamyl Cycle) Amino Acid & Nitrogen Metabolism · Cytosol
Xenobiotic/electrophile + GSH -> GS-conjugate -> mercapturic acid
Converts Xenobiotic/electrophile Glutathione (GSH) into GS-conjugate
› Notes
Phase II conjugation; depletion of GSH by NAPQI underlies paracetamol (acetaminophen) hepatotoxicity, treated with N-acetylcysteine.
Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER
Electrophile + GSH -> GS-conjugate -> mercapturic acid
Converts Glutathione (GSH) into GS-conjugate
› Notes
Detoxifies reactive intermediates such as NAPQI from paracetamol.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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