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unreviewed

Glutamate-aspartate antiporter (citrin/aralar, SLC25A13/12)

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Malate-Aspartate Shuttle Energy Metabolism & Cellular Respiration · Cytosol + inner mitochondrial membrane

step 5 Irreversible/directional

Aspartate(matrix) + glutamate(cytosol) -> aspartate(cytosol) + glutamate(matrix)

Converts Aspartate(matrix) Glutamate into Aspartate(cytosol) Glutamate

› Notes

Completes the cycle; cytosolic AST (GOT1) then reforms oxaloacetate. Dominant shuttle in liver, kidney and heart.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Granulocyte differentiation arrest in HAX1-deficient cells, demonstrated in a new in vitro model of a certain phenotypic aspects of Kostmann disease, is caused by ineffective lipid droplet autophagy and fatty acids uptake.

    Wakula M, Jablonowska M, Chmielarczyk M, Tarnowski L, Kulinczak M, Sitkiewicz E, Swiderska B, Samborowska E, … · 2026-05-05

    open access unreviewed
  2. 2
    Computational modeling of cancer cell metabolism along the catabolic-anabolic axes.

    Villela-Castrejon J, Levine H, Kaipparettu BA, Onuchic JN, George JT, Jia D. · 2025-05-10

    cited 3× open access unreviewed
  3. 3
    Transcriptome Analysis of Goat Mammary Gland Tissue Reveals the Adaptive Strategies and Molecular Mechanisms of Lactation and Involution.

    Xuan R, Wang J, Zhao X, Li Q, Wang Y, Du S, Duan Q, Guo Y, Ji Z, Chao T. · 2022-11-20

    cited 19× open access unreviewed
  4. 4
    Mitochondrial diseases: expanding the diagnosis in the era of genetic testing.

    Saneto RP. · 2020-09-29

    cited 19× open access unreviewed
  5. 5
    A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics.

    MacDonald JA, Bothun AM, Annis SN, Sheehan H, Ray S, Gao Y, Ivanov AR, Khrapko K, Tilly JL, Woods DC. · 2019-07-11

    cited 44× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.