Glutamate decarboxylase (GAD65/GAD67)
Cofactors used
Clinical / pharmacological. B6-dependent; anti-GAD antibodies in stiff-person syndrome and T1DM
What it does, reaction by reaction
Other Neurotransmitter Synthesis Amino Acid & Nitrogen Metabolism · Cytosol
L-Glutamate -> GABA + CO2
Converts Glutamate into GABA CO2
› Notes
B6 deficiency (e.g. isoniazid without pyridoxine) lowers GABA and causes seizures. Anti-GAD antibodies occur in stiff-person syndrome and type 1 diabetes.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
The Arabic Generalized Anxiety Disorder 2 (GAD-2): Psychometric evaluation among mothers of children with intellectual disabilities.
Ali AM, Al-Dossary SA, Fekih-Romdhane F, Laranjeira C, Khatatbeh H, El-Gazar HE, Ayed A, Alkhamees AA, Aljabe… · 2026-05-05
cited 1× open access unreviewed -
2
Proteomic mapping of Rosa damascena nanovesicles reveals plastid mitochondrial metabolic convergence and antimicrobial peptides.
Brahadeeswaran S, Tamizhselvi R. · 2026-03-09
open access unreviewed -
3
Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner.
Ahmad R, Zobel G, Hannaford R, Maclean P, Olson T, Hurst C, Bracegirdle J, Young W, Rettedal E, Anderson RC, … · 2026-06-08
open access unreviewed -
4
Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems.
Yang WS, Choe MS, Lo C, Liu HW, Cho YM, Kim J, Kiral FR, Scandura M, Lu X, Kim KY, Na K, Qiu C, Wu F, Dirks A… · 2026-05-25
unreviewed -
5
Neurodevelopmental effects of early life stress: PFC and cognition.
Rachmany L, Abreu F, Walker V, O'Neill O, Sargin D, Teixeira CM. · 2026-03-27
cited 1× unreviewed -
6
Desloratadine Rescues Schizophrenia-like Phenotypes by Inhibiting the Pathogenic 5-HT2AR-PI3K/AKT/mTOR Signaling Axis.
Yao Y, Zhao W, Chen J, Wang S, Song Z, Sun L, Hu Y, Li L. · 2026-06-24
open access unreviewed -
7
Endogenously generated Dutch-type Aβ non-fibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation.
Castranio EL, Varghese M, Argyrousi EK, Tripathi K, Huang Y, Asada A, Söderberg L, Bresnahan E, Lerner D, Gar… · 2026-06-01
open access unreviewed -
8
Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience.
Lu A, Chen WT, Dalby M, Sainz Garcia D, Vanheusden M, de Vries LE, van Lieshout V, Martirosyan A, Craessaerts… · 2026-06-04
cited 3× open access unreviewed -
9
Prefrontal Cortex Dysregulation of Amino Acid-Glucose Homeostasis Links High-Fat and/or High-Fructose Intake to Cognitive Deficits in Male Mice.
Martínez-Orozco H, Reyes-Castro LA, Lomas-Soria C, Solís-Ortíz S, Diaz-Miranda SY. · 2026-06-02
open access unreviewed -
10
RECOMBINE identifies recurrent composite markers of cell types and states.
Li X, Nguyen J, Korkut A. · 2026-06-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.