Glutamate decarboxylase (GAD65/GAD67)
Cofactors used
Clinical / pharmacological. B6-dependent; anti-GAD antibodies in stiff-person syndrome and T1DM
What it does, reaction by reaction
Other Neurotransmitter Synthesis Amino Acid & Nitrogen Metabolism · Cytosol
L-Glutamate -> GABA + CO2
Converts Glutamate into GABA CO2
› Notes
B6 deficiency (e.g. isoniazid without pyridoxine) lowers GABA and causes seizures. Anti-GAD antibodies occur in stiff-person syndrome and type 1 diabetes.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Therapeutic potential and underlying mechanisms of engineered young plasma-derived exosomes in Alzheimer's disease.
Chen H, Si Y, Cheng Q, Yu Q, Cui Z, Yu S, Zhao X, Jin Y, Wang Y, Li M, Lu Z. · 2026-08-15
open access unreviewed -
2
The Arabic Generalized Anxiety Disorder 2 (GAD-2): Psychometric evaluation among mothers of children with intellectual disabilities.
Ali AM, Al-Dossary SA, Fekih-Romdhane F, Laranjeira C, Khatatbeh H, El-Gazar HE, Ayed A, Alkhamees AA, Aljabe… · 2026-05-05
cited 1× open access unreviewed -
3
Proteomic mapping of Rosa damascena nanovesicles reveals plastid mitochondrial metabolic convergence and antimicrobial peptides.
Brahadeeswaran S, Tamizhselvi R. · 2026-03-09
cited 1× open access unreviewed -
4
<i>CACNA1C</i> Genetic Variants Differentially Affect Neuronal Networks Through Divergent Pathways.
Wilkinson G, Wood J, Roivainen N, Haddon JE, Underwood JFG, Hall J, Harwood AJ. · 2026-07-22
open access unreviewed -
5
Transcriptomic analysis reveals differential regulation of synaptic components in pediatric and adult brain tumors
· 2026-10-01
open access unreviewed -
6
Identification of a CD44-dependent control of astrocytic autophagic activity in Alzheimer's disease.
Wang H, Long Y, Tang Y, Duan L, Wang Z, Zhang S, Yin Y, Zhou J, Wu W, Zhong C. · 2026-05-20
open access unreviewed -
7
Recording proteome dynamics in the late-stage embryo at hour-timescale, spatial, and single-cell resolution with MEMBRYO
· 2026-09-28
open access unreviewed -
8
Pervasive Somatic Mutations in NF1 Drive Cell Type and Spatially Specific Clonal Selection in Neurofibromatosis
· 2026-09-30
open access unreviewed -
9
Chlorogenic acid attenuates TBI-induced neuroinflammation by suppressing cGAS-STING signaling.
Yang X, He K, Zhang Y, Dang H, Wang Z, Zhang Y, Zhang C, Chen P, Zhang T, Zhang L, Yu Y. · 2026-09-28
open access unreviewed -
10
PLXDC2 siRNA-Mediated Intervention Attenuates Microglial Senescence Through cGAS-STING Signaling.
Lu H, Zheng Z, Wang F, Luo H, Ju F, Zhu Y, Zhou Z, Sun J, Qiu Z, Luo X, Jia Z, Wang J, Huang H, Zhang B. · 2026-09-27
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.