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unreviewed

Glucocerebrosidase (GBA)

1 reactions · 1 pathways

Clinical / pharmacological. Gaucher disease; GBA variants also raise Parkinson disease risk

What it does, reaction by reaction

1 reactions

Sphingolipid Degradation (Lysosomal) Lipid Metabolism · Lysosome

step 4 Irreversible/directional

Glucosylceramide -> ceramide + glucose

Converts Glucosylceramide into Ceramide Glucose

› Notes

Deficiency causes Gaucher disease, the commonest lysosomal storage disorder (Gaucher cells, bone crises, pancytopenia).

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    DNA methylation-estimated phenotypes, telomere length, aging and risk of intracranial aneurysms: Evidence from genetic studies.

    Zhang X, Maimaiti A, Xie M, Turhon M, Yalikun N, Liang W. · 2026-05-30

    open access unreviewed
  2. 2
    Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.

    Aolymat I, Abu-Hassan DW, Oleimat AK, Sameer W, Wreikat B, Iqilan T, Al-Momani H, Ali H, Tahtamouni L, Iqsair… · 2026-06-03

    open access unreviewed
  3. 3
    Non-immune hydrops fetalis (NIHF): diagnostic evaluation and lessons learned from a case series.

    Al Hassan J, Yared G, El Hajjar C, Dahrouj M, Massaad C, El Moghrabi A, Ghazal K. · 2026-06-03

    open access unreviewed
  4. 4
    Endoplasmic reticulum stress-related genes drive M1 macrophage polarization in preeclampsia via modulating metabolic reprogramming: a bioinformatic study.

    Xu C, Hu R, Lu Y, Gu L, Xu H, Huang X. · 2026-03-26

    unreviewed
  5. 5
    A 4-guanidinobutanoic acid-SLC36A1 axis drives a microbiota‒host feedback loop to regulate intestinal homeostasis.

    Yang J, Xiao Y, Cui J, Song R, Ma W, Liu J, Miao C, Sun X, Kong X, Zhang ZS, Zhou L, Yao Z, Wang Q. · 2026-03-04

    cited 1× open access unreviewed
  6. 6
    An Rv1471-expressing chimpanzee adenovirus vaccine confers protection against tuberculosis by inducing alveolar macrophage trained immunity and polyfunctional T-cell responses.

    Wang H, Zhang Y, Li J, Wu J, Huang S, Xie S, Huang X, Wang J, Fan XY, Hu Z. · 2026-03-10

    open access unreviewed
  7. 7
    Current potential biomarkers for Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis: review of literature.

    Peng J, Fan T, Wang J, Deng Y, Xu R. · 2026-02-06

    open access unreviewed
  8. 8
    GBA mutation exacerbates α-synuclein pathology with involvement of ROS and p38 MAPK signaling in Parkinson's disease.

    Xu H, Tang YT, Dong WL, Liu MH, Wang F, Liu CF, Chen JP. · 2026-06-30

    unreviewed
  9. 9
    Probiotic, prebiotic, and synbiotic interventions targeting the early-life gut-brain axis: A systematic review of randomized controlled trials.

    Carnazzo SM, Vitello A, Allia F, Graziano ACE, Praticò AD, Maida M. · 2026-06-18

    unreviewed
  10. 10
    Impacts of underwater low-frequency noise during the operational phase of offshore wind farms on juvenile black scraper (Thamnaconus modestus).

    Song S, Shan X. · 2026-06-09

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.