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unreviewed

Glucocerebrosidase (GBA)

1 reactions · 1 pathways

Clinical / pharmacological. Gaucher disease; GBA variants also raise Parkinson disease risk

What it does, reaction by reaction

1 reactions

Sphingolipid Degradation (Lysosomal) Lipid Metabolism · Lysosome

step 4 Irreversible/directional

Glucosylceramide -> ceramide + glucose

Converts Glucosylceramide into Ceramide Glucose

› Notes

Deficiency causes Gaucher disease, the commonest lysosomal storage disorder (Gaucher cells, bone crises, pancytopenia).

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Development of a new recombineering system for <i>Edwardsiella</i> species.

    Deng Y, Sun J, Ji H, Qu M, Zhu J, Meng X, Ma Y, Liu J, Xu S, Liu Z, Zhang Y, Fu J, Li A, Li R. · 2026-08-24

    open access unreviewed
  2. 2
    Gut bacteria and their metabolites may influence our decisions, intelligence, cognition, and consciousness.

    Dicks LMT, Botha A, Pohl C. · 2026-10-03

    open access unreviewed
  3. 3
    Clinical course and biomarkers in patients with type 1 Gaucher disease and Parkinson's disease: A retrospective cohort study.

    Iverson A, Sinha DB, Fierro L, Stauffer C, Naik H, Alcalay RN, Balwani M. · 2026-09-16

    open access unreviewed
  4. 4
    Computational evaluation of EPA-PC binding to GCase in neuronopathic Gaucher disease.

    Nagori R, Rai PK, Solanki M, Sabharwal U, Patel P. · 2026-09-08

    open access unreviewed
  5. 5
    Therapeutic modulation of the gut-brain axis in alcohol use disorder: A systematic review.

    Bhandari P, Sideeg A, Elfeki M, Xie C, Singal AK. · 2026-09-07

    open access unreviewed
  6. 6
    Bio-derived lignin nanospheres as active interfacial regulators in defect-rich W<sub>18</sub>O<sub>49</sub> electrochromic nanocomposites.

    Tan J, Ma B, Qin Y, Qiu X, Chen L. · 2026-07-31

    unreviewed
  7. 7
    Branched-chain amino acids and gut microbiota: coregulation and impact on neurological function via the gut-brain axis.

    Li Q, Fan B, Xiao Y, Zhang Z, Zhao S, Liao B, Zeng J, Shan X, Ye H, Wen Y, Zhang L, Guo H, Xiao F, Zhu H. · 2026-07-14

    open access unreviewed
  8. 8
    DNA methylation-estimated phenotypes, telomere length, aging and risk of intracranial aneurysms: Evidence from genetic studies.

    Zhang X, Maimaiti A, Xie M, Turhon M, Yalikun N, Liang W. · 2026-05-30

    open access unreviewed
  9. 9
    Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.

    Aolymat I, Abu-Hassan DW, Oleimat AK, Sameer W, Wreikat B, Iqilan T, Al-Momani H, Ali H, Tahtamouni L, Iqsair… · 2026-06-03

    open access unreviewed
  10. 10
    Non-immune hydrops fetalis (NIHF): diagnostic evaluation and lessons learned from a case series.

    Al Hassan J, Yared G, El Hajjar C, Dahrouj M, Massaad C, El Moghrabi A, Ghazal K. · 2026-06-03

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.