unreviewed
Glucocerebrosidase (GBA)
1 reactions · 1 pathways
Clinical / pharmacological. Gaucher disease; GBA variants also raise Parkinson disease risk
What it does, reaction by reaction
1 reactions
Sphingolipid Degradation (Lysosomal) Lipid Metabolism · Lysosome
step 4
Irreversible/directional
Glucosylceramide -> ceramide + glucose
Converts Glucosylceramide into Ceramide Glucose
› Notes
Deficiency causes Gaucher disease, the commonest lysosomal storage disorder (Gaucher cells, bone crises, pancytopenia).
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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