What it does, reaction by reaction
Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane
Arachidonic acid + O2 -> 5-HPETE -> LTA4
Converts Arachidonic acid O2 into 5-HPETE
› Notes
Branch point of the leukotriene arm; zileuton inhibits 5-LOX.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
The dual role of leukotrienes in the tumor microenvironment: balancing pro-tumorigenic and anti-tumor immunity.
Thake A, Caruso M, Fernandez-Bussy S, Sacco K. · 2026-06-23
unreviewed -
2
Whole transcriptome sequencing reveals differences in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia.
Zhou M, Li T, Li Y, Chen Y, Zhuang W, Ouyang G. · 2026-03-02
unreviewed -
3
Multi-omics dissection of metabolic hijacking: Infectious bronchitis virus orchestrates lipid-centric replication through PPAR-TGF-β crosstalk.
Yan K, Wang X, Bo Z, Zhang C, Guo M, Zhang X, Wu Y. · 2026-01-28
cited 1× open access unreviewed -
4
Metabolic control of macrophages in coronavirus disease 2019.
An L, Xu H, Fan Q, Lu M, Sun D. · 2025-12-26
open access unreviewed -
5
Urinary leukotriene E4 for predicting steroid sensitivity in children with nephrotic syndrome: an observational cohort study.
Saad N, Osman A, Mansour M, Bakr AM. · 2025-09-30
open access unreviewed -
6
Garcinoic acid: A vitamin E metabolite-mimetic scaffold linking nuclear receptor pharmacology to inflammatory signaling and biomimetic drug discovery.
Migni A, Cerra B, Passeri D, Galli C, Ceccarini MR, Varfaj I, Sozen E, Surh YJ, Ozer NK, Schoubben AMM, Caval… · 2026-07-22
unreviewed -
7
ALOX5 mediates sunitinib resistance in renal cell carcinoma by reprogramming lipid metabolism through the p38/ERK/PPARα axis.
Di S, Liu J, Gu Z, Jin C, Zhang J, Li K, Liu Y, Chen H, Yang W, Chen W, Zhang W, Mao S, Hao Y, Zhang H, Zhu X… · 2026-06-13
unreviewed -
8
Ubiquitination-dependent regulation of ferroptosis in ischemic heart and brain.
Zhang YY, Long XY, Tian J, Luo XJ, Peng J. · 2026-06-08
open access unreviewed -
9
Multi-omic profiling identifies TREM2<sup>+</sup> lipid-laden macrophages as inflammatory drivers and therapeutic targets of colorectal cancer liver metastasis.
Wang PX, Zhong YC, Zheng WJ, Xian JR, Song F, Xu J, Sun YF, Cheng JW, Feng HY, Jiang X, Xu Y, Zhang ZF, Zhou … · 2026-06-06
unreviewed -
10
The irony of Parkinson's disease: Converging mechanisms of redox imbalance and ferroptosis.
Cooke LE, Rocha E, DiMaio R, Straub AC, Fazzari M. · 2026-05-27
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.