What it does, reaction by reaction
Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane
Arachidonic acid + O2 -> 5-HPETE -> LTA4
Converts Arachidonic acid O2 into 5-HPETE
› Notes
Branch point of the leukotriene arm; zileuton inhibits 5-LOX.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Single-cell RNA sequencing uncovers an immunosuppressive program in PDAC mast cells: tumour-driven activation, proliferation, and association with Treg recruitment.
Wu M, Ye X, Yu Q, Huang H, Zhang Z, Yu X, Lou S, Xu J. · 2026-08-31
open access unreviewed -
2
The dual role of leukotrienes in the tumor microenvironment: balancing pro-tumorigenic and anti-tumor immunity.
Thake A, Caruso M, Fernandez-Bussy S, Sacco K. · 2026-06-23
open access unreviewed -
3
Whole transcriptome sequencing reveals differences in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia.
Zhou M, Li T, Li Y, Chen Y, Zhuang W, Ouyang G. · 2026-03-02
unreviewed -
4
Multi-omics dissection of metabolic hijacking: Infectious bronchitis virus orchestrates lipid-centric replication through PPAR-TGF-β crosstalk.
Yan K, Wang X, Bo Z, Zhang C, Guo M, Zhang X, Wu Y. · 2026-01-28
cited 1× open access unreviewed -
5
Metabolic control of macrophages in coronavirus disease 2019.
An L, Xu H, Fan Q, Lu M, Sun D. · 2025-12-26
open access unreviewed -
6
Urinary leukotriene E4 for predicting steroid sensitivity in children with nephrotic syndrome: an observational cohort study.
Saad N, Osman A, Mansour M, Bakr AM. · 2025-09-30
open access unreviewed -
7
Rutin alleviates LPS-induced injury in IPEC-J2 cells via suppression of ferroptosis: involvement of NFE2L2-KEAP1, TLR4 and ALOX5.
Huo L, Liu J, Li M, Tian W, Wang B, Cao H, Luo G, Shen M, Liu J. · 2026-08-10
unreviewed -
8
DANGER/ITPRIP-mediated iron homeostasis mediates ferroptosis resistance and presents a potential therapeutic target in ccRCC.
Fan K, Zhou Y, Xu J, Mathis BJ, Hao J, Feng Y, Lin J, Yu X, Liu S, Sun D, Wu W. · 2026-07-14
unreviewed -
9
Carbon nanoparticle-Fe (II) complex for ferroptosis therapy in refractory solid tumors: a phase I trial.
Shi H, Xie P, Li X, Lai L, Dang Q, Gou Z, Liao Z, He Q, Guo W, Ding Z, Wu S, Chen Y, Lin Z, Wen Y, Huang Y, C… · 2026-10-01
open access unreviewed -
10
Enrichment and Proteomic Profiling of Stromal-Associated Extracellular Vesicle Subpopulations From Arthritic Synovial Fluid by Size-Exclusion Chromatography Coupled to CD90-Directed Immunocapture.
Kurth S, Hanser E, Häner-Massimi S, Giaglis S, Geier F, Burri D, Buczak K, Heider U, Wild S, Acklin YP, Eglof… · 2026-10-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.