What it does, reaction by reaction
Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER
DMAPP + IPP → geranyl pyrophosphate (GPP) + PPi
Converts Dimethylallyl pyrophosphate (DMAPP) Isopentenyl pyrophosphate (IPP) into Geranyl pyrophosphate (GPP) PPi
› Notes
Geranyl pyrophosphate synthase carries out a head-to-tail prenyl transfer to form the C10 isoprenoid. Pyrophosphate release helps drive the reaction.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Multi-omics studies identified the molecular network of mitochondrial dysfunction in the pathogenesis of breast cancer.
Liu J, Guan X, Quan L, Dou M, Yuan P. · 2026-05-17
open access unreviewed -
2
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.
Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28
open access unreviewed -
3
<i>Agathobacter rectalis</i> suppresses colorectal tumorigenesis via an epigallocatechin-SREBF2 axis controlling cholesterol metabolism.
Lu J, Sun Y, Zeng Y, Lau EYT, Lan Z, Ye S, Zhang R, Hu R, Cui C, Liang JQ. · 2026-08-28
open access unreviewed -
4
Clinical outcomes of zirconia dental restorations: A systematic review and meta-analysis.
Ma Y, Xuan Y, Cheng W, Zhang S, Fu B. · 2026-08-10
unreviewed -
5
The gut-bone axis: microbial metabolism and nutritional interventions for bone health.
Rodriguez-Bryant A, Papageorgiou M, Horcajada MN, Biver E, Ferrari S, Bonnet N. · 2026-05-22
cited 3× open access unreviewed -
6
Molecular mechanisms of folliculogenesis and oogenesis.
Ezz MA, Balboula AZ. · 2026-04-02
cited 4× open access unreviewed -
7
The role of large language models in dental diagnosis, decision-making, and communication: A systematic review.
Kaplan TT, Akyol GE. · 2026-01-27
cited 7× open access unreviewed -
8
Gypenosides Damulin A and Damulin B Inhibit Hepatocellular Carcinoma by Regulating Cholesterol Synthesis.
Li FF, Cui C, Zheng ZJ, Xiao MY, Li S, Xie P, Piao XL. · 2026-11-01
unreviewed -
9
In silico structural characterization of the geranyl pyrophosphate synthase (GPPS) large subunit from Catharanthus roseus.
Yadav K, Gupta KA, Nagegowda DA, Vasudev PG. · 2026-07-22
unreviewed -
10
Fracture resistance of 3D printed resin-based permanent ceramic fixed dental prostheses after thermocycling.
Ozer S, Akgun BA, Cakan U. · 2026-07-16
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.