Fructose-bisphosphate aldolase (Aldolase A/B/C)
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Glyceraldehyde-3-phosphate + dihydroxyacetone phosphate → fructose-1,6-bisphosphate
Converts Glyceraldehyde-3-phosphate Dihydroxyacetone phosphate into Fructose-1,6-bisphosphate
› Notes
Fructose-bisphosphate aldolase catalyzes reversible aldol condensation. No ATP is used.
Glycolysis Carbohydrate Metabolism · Cytosol
Fructose-1,6-bisphosphate → glyceraldehyde-3-phosphate + dihydroxyacetone phosphate
Converts Fructose-1,6-bisphosphate into Glyceraldehyde-3-phosphate Dihydroxyacetone phosphate
› Notes
Fructose-bisphosphate aldolase reversibly cleaves the six-carbon ketose bisphosphate into two phosphorylated trioses. No redox cofactor or ATP is required.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Synaptic Plasticity Fragility Underlies a Microglial Pruning Continuum in Major Depressive Disorder and Amyotrophic Lateral Sclerosis.
Cheung N. · 2026-04-17
open access unreviewed -
2
Lomitapide mesylate and lomitapide target ALDOA to inhibit growth and enhance gemcitabine efficacy in PDAC.
Liu YJ, Zhao FY, Wang JM, Li BQ, Lu SY, Li C, Wang HQ. · 2026-03-11
open access unreviewed -
3
Glycogen storage disease type IX: Long-term follow-up of 52 patients from three European countries.
Magner M, Šáhó R, Slavíková P, Bakaľár R, Dvořáková L, Pešková K, Ramadža DP, Barić I, Ilic N, Čechová A, Řeb… · 2026-02-14
open access unreviewed -
4
Combined Analysis of the Transcriptome and Metabolome at Different Tissue Glycogen Levels in Yili Horses.
Li X, Qian S, Yang L, Yang X, Chang X, Zeng Y, Meng J. · 2026-02-19
open access unreviewed -
5
ALDOC modulates astrocytic glycolysis and AMPK/mTOR/HIF-1α signaling in Alzheimer's disease.
Zhang Z, Bai Y, Zhang X, Zhang J, Yang G. · 2026-06-04
open access unreviewed -
6
Association of SNPs in carbohydrate metabolism genes with insulin resistance indicators in the Mexican population.
Méndez-García A, Aguilar-Galarza A, García-Muñoz W, Araujo-Mendoza JB, García-Gasca T, Anaya-Loyola MA, Kuri-… · 2025-07-01
cited 2× open access unreviewed -
7
Multitissue single-cell analysis reveals differential cellular and molecular sensitivity between fructose and high-fat high-sucrose diets.
Chen YW, Ahn IS, Wang SS, Majid S, Diamante G, Cely I, Zhang G, Cabanayan A, Komzyuk S, Bonnett J, Arneson D,… · 2025-05-10
cited 7× open access unreviewed -
8
IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia.
Horn S, Schmid M, Berest I, Piattini F, Zhang J, de Bock K, Devuyst O, Nlandu Khodo S, Kisielow J, Kopf M. · 2025-03-17
cited 7× open access unreviewed -
9
In Silico Analysis of Saroglitazar and Ferulic Acid Binding to Human Ketohexokinase: Implications for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Tiwari K, Kumar B, Tiwari A, Dhamija P, Vardhan G, Dehade A, Kumar V. · 2025-02-22
cited 1× open access unreviewed -
10
Metabolic reprogramming of glucose: the metabolic basis for the occurrence and development of hepatocellular carcinoma.
Wang K, Li X, Guo S, Chen J, Lv Y, Guo Z, Liu H. · 2025-02-06
cited 6× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.