Fructose-bisphosphate aldolase (Aldolase A/B/C)
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Glyceraldehyde-3-phosphate + dihydroxyacetone phosphate → fructose-1,6-bisphosphate
Converts Glyceraldehyde-3-phosphate Dihydroxyacetone phosphate into Fructose-1,6-bisphosphate
› Notes
Fructose-bisphosphate aldolase catalyzes reversible aldol condensation. No ATP is used.
Glycolysis Carbohydrate Metabolism · Cytosol
Fructose-1,6-bisphosphate → glyceraldehyde-3-phosphate + dihydroxyacetone phosphate
Converts Fructose-1,6-bisphosphate into Glyceraldehyde-3-phosphate Dihydroxyacetone phosphate
› Notes
Fructose-bisphosphate aldolase reversibly cleaves the six-carbon ketose bisphosphate into two phosphorylated trioses. No redox cofactor or ATP is required.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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