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unreviewed

Farnesyl pyrophosphate synthase

1 reactions · 1 pathways

Cofactors used

PPi

What it does, reaction by reaction

1 reactions

Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER

step 10 Irreversible/directional

GPP + IPP → farnesyl pyrophosphate (FPP) + PPi

Converts Geranyl pyrophosphate (GPP) Isopentenyl pyrophosphate (IPP) into Farnesyl pyrophosphate (FPP) PPi

› Notes

Farnesyl pyrophosphate synthase performs the next head-to-tail condensation, forming C15 FPP. FPP is also a branch-point precursor for ubiquinone, dolichol, and protein prenylation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Multi-omics studies identified the molecular network of mitochondrial dysfunction in the pathogenesis of breast cancer.

    Liu J, Guan X, Quan L, Dou M, Yuan P. · 2026-05-17

    open access unreviewed
  2. 2
    Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.

    Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28

    open access unreviewed
  3. 3
    Highly efficient production of <i>β</i>-caryophyllene in <i>Saccharomyces cerevisiae</i> using a novel synthase from <i>Artemisia argyi</i>.

    Xiao X, Wan X, Lu H, Cheng W, Liu J, Jiang H, Zhi Y, Chen F, Yang J, Er L, Lu L, Yao G. · 2026-06-25

    open access unreviewed
  4. 4
    Plant essential oils against woody plant fungal pathogens: chemical composition, antifungal mechanisms, and translational challenges.

    Alizadeh M. · 2026-09-18

    open access unreviewed
  5. 5
    Lipid metabolism dysregulation in Parkinson's disease: A Mendelian randomization and transcriptomic analysis.

    Calikusu FZ, Chen S, Wang T, Li D. · 2026-08-26

    open access unreviewed
  6. 6
    <i>Agathobacter rectalis</i> suppresses colorectal tumorigenesis via an epigallocatechin-SREBF2 axis controlling cholesterol metabolism.

    Lu J, Sun Y, Zeng Y, Lau EYT, Lan Z, Ye S, Zhang R, Hu R, Cui C, Liang JQ. · 2026-08-28

    open access unreviewed
  7. 7
    Clinical outcomes of zirconia dental restorations: A systematic review and meta-analysis.

    Ma Y, Xuan Y, Cheng W, Zhang S, Fu B. · 2026-08-10

    unreviewed
  8. 8
    The gut-bone axis: microbial metabolism and nutritional interventions for bone health.

    Rodriguez-Bryant A, Papageorgiou M, Horcajada MN, Biver E, Ferrari S, Bonnet N. · 2026-05-22

    cited 3× open access unreviewed
  9. 9
    Constructing an efficient synthesis pathway in peroxisomes to boost <i>β</i>-myrcene production in yeast.

    Chang J, Wang J, Dong T, Shu Y, Wang Y, Xiao W, Yao M, Yuan Y. · 2026-04-25

    open access unreviewed
  10. 10
    Molecular mechanisms of folliculogenesis and oogenesis.

    Ezz MA, Balboula AZ. · 2026-04-02

    cited 4× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.