FAS malonyl/acetyl transferase (MAT) domain
Cofactors used
What it does, reaction by reaction
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Acetyl-CoA + ACP → acetyl-ACP + CoA-SH
Converts Acetyl-CoA ACP (acyl carrier protein) into Acetyl-ACP CoA-SH
› Notes
The acetyl group is transferred by the acetyl/malonyl transferase activity of the multifunctional fatty acid synthase complex to its acyl-carrier protein (ACP) phosphopantetheine thiol; the acetyl group is then transferred to the active-site cysteine of the β-ketoacyl synthase (KS) domain. ACP contains 4′-phosphopantetheine, derived from pantothenate.
Malonyl-CoA + ACP → malonyl-ACP + CoA-SH
Converts Malonyl-CoA ACP (acyl carrier protein) into Malonyl-ACP CoA-SH
› Notes
The FAS malonyl/acetyl transferase loads malonyl-CoA onto ACP. One acetyl primer and seven malonyl units are required to make palmitate.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
3D-printed niche-matched GelMA-dECM bioinks rewire lipid metabolic reprogramming and chemosensitization in pancreatic ductal adenocarcinoma.
Zhu B, Yang T, Chang M, Li Y, Wu D, Yan J, Guo Q, Wan J, Guo Y, Lu Y. · 2026-08-20
unreviewed -
2
VCP at the crossroads of UPS and autophagy in cancer.
Hitchman CJ, Phillips JI, Park HW, Lu H. · 2026-05-28
open access unreviewed -
3
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.
Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28
open access unreviewed -
4
Pharmacological inhibition of CLPP stabilizes LETMD1 to boost thermogenesis and alleviate obesity.
Yuan H, Deng Y, Wang J, Luan B, Zhang ZN. · 2026-09-30
open access unreviewed -
5
Low-dose l-carnitine supplementation attenuates hepatic lipid accumulation in chow-fed mice: Insights from integrated multi-omics analysis.
Zhang Z, Ding B, Zhang L, Zhang L, Huang Y. · 2026-09-10
open access unreviewed -
6
From candidate genes to whole-genome approaches: current insights into the genetic architecture of ovine milk production and quality traits.
Mastrangelo S, Benanti A, Tumino S, Criscione A, Cesarani A. · 2026-09-15
open access unreviewed -
7
Effects of <i>Lactobacillus acidophilus</i> on hepatic and microbial dysregulation in MASLD and diabetes.
Park HJ, Park IG, Park JH, Park HJ, Jung JJ, Han SH, Suk KT. · 2026-09-19
open access unreviewed -
8
Hepatocyte SLC31A1-dependent copper accumulation contributes to hepatic glucose and lipid metabolic disturbances through AMPKα1 inactivation.
Cheng YQ, Wei M, Yang L, Zhuang YY, Lu QB. · 2026-09-11
open access unreviewed -
9
Distinct functional roles of <i>Lactobacillus</i> strains in modulating lipid metabolism, adipose accumulation, inflammatory responses, and carcass characteristics in heavy finishing pigs.
Wan B, Zeng Q, He L, Qin X, Tan M, Yan E, Liao J, Li Z, Zhang X, Yin J. · 2026-07-31
open access unreviewed -
10
Epigallocatechin gallate (EGCG) inhibits African swine fever virus replication by targeting key viral proteins and regulating host lipid metabolism.
He X, Li H, Yang R, Li P, Wang G, Cao H, Sun Y, Zhang M, Li Y, Shi K, Jongkaewwattana A, Ruan S, Li W. · 2026-09-18
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.