F0F1-ATP synthase (Complex V), F0 sector
Clinical / pharmacological. Inhibited by oligomycin; bypassed by uncouplers (DNP, UCP1)
What it does, reaction by reaction
Oxidative Phosphorylation (Chemiosmotic Mechanism and ATP Synthase) Energy Metabolism & Cellular Respiration · Inner mitochondrial membrane
H+intermembrane space → H+matrix through F0; rotation of the c-ring and gamma shaft
Converts H+ (intermembrane space)
› Notes
The membrane-embedded F0 sector contains the a subunit and rotating c-ring: protonation/deprotonation of conserved c-subunit carboxylates drives c-ring rotation relative to the stator. Required condition/cofactor: the proton-motive force and intact F0; oligomycin binds F0 and blocks proton flow, thereby inhibiting ATP synthesis and secondarily slowing respiration.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Oxidative Phosphorylation (Chemiosmotic Mechanism and ATP Synthase)
Listed there as: F0F1-ATP synthase (Complex V)
ADP, Pi, adequate proton-motive force
Oligomycin; IF1 can inhibit ATP hydrolysis under conditions of mitochondrial depolarization
Thyroid hormone and endurance training can raise mitochondrial oxidative capacity over time; acute control follows ADP/Pi availability
Recent literature
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